Sex determination in humans

被引：43

作者：

Schafer, AJ

Goodfellow, PN

机构：

[1] Department of Genetics, University of Cambridge, Cambridge CB2 3EH, Downing Street

来源：

BIOESSAYS | 1996年 / 18卷 / 12期

基金：

英国惠康基金;

关键词：

D O I：

10.1002/bies.950181205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammals, the Y chromosome induces testis formation and thus male sexual development; in the absence of a Y chromosome, gonads differentiate into ovaries and female development ensues. Molecular genetic studies have identified the Y-located testis determining gene SRY as well as autosomal and X-linked genes necessary for gonadal development. The phenotypes resulting from mutation of these genes, together with their patterns of expression, provide the basis for establishing a hierarchy of genes and their interactions in the mammalian sex determination pathway.

引用

收藏

页码：955 / 963

页数：9

相关论文

共 84 条

[1] A DOSAGE SENSITIVE LOCUS AT CHROMOSOME XP21 IS INVOLVED IN MALE TO FEMALE SEX REVERSAL [J].

BARDONI, B ;

ZANARIA, E ;

GUIOLI, S ;

FLORIDIA, G ;

WORLEY, KC ;

TONINI, G ;

FERRANTE, E ;

CHIUMELLO, G ;

MCCABE, ERB ;

FRACCARO, M ;

ZUFFARDI, O ;

CAMERINO, G .

NATURE GENETICS, 1994, 7 (04) :497-501

[2] EVIDENCE THAT THE SRY PROTEIN IS ENCODED BY A SINGLE EXON ON THE HUMAN Y-CHROMOSOME [J].

BEHLKE, MA ;

BOGAN, JS ;

BEERROMERO, P ;

PAGE, DC .

GENOMICS, 1993, 17 (03) :736-739

[3] DELETION 9P AND SEX REVERSAL [J].

BENNETT, CP ;

DOCHERTY, Z ;

ROBB, SA ;

RAMANI, P ;

HAWKINS, JR ;

GRANT, D .

JOURNAL OF MEDICAL GENETICS, 1993, 30 (06) :518-520

[4] MOLECULAR ANALYSIS OF THE SEX-DETERMINING REGION FROM THE Y-CHROMOSOME IN 2 PATIENTS WITH FRASIER SYNDROME [J].

BERTA, P ;

MORIN, D ;

POULAT, F ;

TAVIAUX, S ;

LOBACCARO, JM ;

SULTAN, C ;

DUMAS, R .

HORMONE RESEARCH, 1992, 37 (03) :103-106

[5] OVARY - TESTIS - A MAMMALIAN DILEMMA [J].

BOGAN, JS ;

PAGE, DC .

CELL, 1994, 76 (04) :603-607

[6] ISOLATION AND CHARACTERIZATION OF A ZINC FINGER POLYPEPTIDE GENE AT THE HUMAN CHROMOSOME-11 WILMS TUMOR LOCUS [J].

CALL, KM ;

GLASER, T ;

ITO, CY ;

BUCKLER, AJ ;

PELLETIER, J ;

HABER, DA ;

ROSE, EA ;

KRAL, A ;

YEGER, H ;

LEWIS, WH ;

JONES, C ;

HOUSMAN, DE .

CELL, 1990, 60 (03) :509-520

[7] CIRCULAR TRANSCRIPTS OF THE TESTIS-DETERMINING GENE SRY IN ADULT-MOUSE TESTIS [J].

CAPEL, B ;

SWAIN, A ;

NICOLIS, S ;

HACKER, A ;

WALTER, M ;

KOOPMAN, P ;

GOODFELLOW, P ;

LOVELLBADGE, R .

CELL, 1993, 73 (05) :1019-1030

[8] MUTATIONAL SCREENING OF THE WILMS-TUMOR GENE, WT1, IN MALES WITH GENITAL ABNORMALITIES [J].

CLARKSON, PA ;

DAVIES, HR ;

WILLIAMS, DM ;

CHAUDHARY, R ;

HUGHES, IA ;

PATTERSON, MN .

JOURNAL OF MEDICAL GENETICS, 1993, 30 (09) :767-772

[9] THE HUMAN SRY TRANSCRIPT [J].

CLEPET, C ;

SCHAFER, AJ ;

SINCLAIR, AH ;

PALMER, MS ;

LOVELLBADGE, R ;

GOODFELLOW, PN .

HUMAN MOLECULAR GENETICS, 1993, 2 (12) :2007-2012

[10] SRY PROTEIN ENHANCES TRANSCRIPTION OF FOS-RELATED ANTIGEN-1 PROMOTER CONSTRUCTS [J].

COHEN, DR ;

SINCLAIR, AH ;

MCGOVERN, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (10) :4372-4376

← 1 2 3 4 5 6 7 8 9 →