Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity

被引：9

作者：

Bürkle, A

Beneke, S

Brabeck, C

Leake, A

Meyer, R

Muiras, ML

Pfeiffer, R

机构：

[1] Univ Newcastle Upon Tyne, Wolfson Res Ctr, Inst Ageing & Hlth, Dept Gerontol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[2] Deutsch Krebsforschungszentrum, Abt Tumorvirol, D-6900 Heidelberg, Germany

来源：

EXPERIMENTAL GERONTOLOGY | 2002年 / 37卷 / 10-11期

关键词：

ageing; longevity; poly(ADP-ribose) polymerase-1; DNA base-excision repair; genomic instability;

D O I：

10.1016/S0531-5565(02)00144-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span. (C) 2002 Published by Elsevier Science Inc.

引用

页码：1203 / 1205

页数：3

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