The liver X receptor gene team: Potential new players in atherosclerosis

被引：334

作者：

Repa, JJ

Mangelsdorf, DJ ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Touchstone Ctr Diabet Res, Dept Physiol, Dallas, TX USA

[3] Univ Texas, SW Med Ctr, Touchstone Ctr Diabet Res, Dept Internal Med, Dallas, TX USA

[4] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75235 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 11期

关键词：

D O I：

10.1038/nm1102-1243

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liver X receptors (LXRs) are sterol-responsive transcription factors that regulate expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has implicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs of their downstream targets may provide alternative therapeutic strategies for the management of this disease.

引用

页码：1243 / 1248

页数：6

共 76 条

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