The Greek Goddess, Artemis, reveals the secrets of her cleavage

被引：40

作者：

Jeggo, P ^{[1
]}

O'Neill, P

机构：

[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

[2] MRC, Radiat & Genome Stabil Unit, DNA Damage Grp, Didcot OX11 ORD, Oxon, England

来源：

DNA REPAIR | 2002年 / 1卷 / 09期

关键词：

radiosensitivity; DSB; V(D)J recombination; DNA-PK complex;

D O I：

10.1016/S1568-7864(02)00096-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A recent paper in Cell by Ma et al. [Cell 8 (2002) 781] showed that the protein Artemis cleaves a hairpin intermediate during V(D)J recombination. Peter O'Neill and Penny Jeggo discuss this finding in the light of evidence that Artemis also functions to repair radiation damage [Cell 105 (2001) 177]. The findings suggest that Artemis may function in double strand break repair by "tidying up" double strand ends with associated base damage. The development of genetic diversity during immune development, therefore, seems to exploit damage response mechanisms that function to maintain genetic stability in other cell lineages. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：771 / 777

页数：7

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