Med-psych drug-drug interactions update - Triptans

被引：13

作者：

Armstrong, SC

Cozza, KL

机构：

[1] Tual Forest Grove Hosp, Ctr Geriatr Psychiat, Forest Grove, OR 97116 USA

[2] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[3] Walter Reed Army Med Ctr, Dept Med, Infect Dis Serv, Washington, DC 20307 USA

[4] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA

来源：

PSYCHOSOMATICS | 2002年 / 43卷 / 06期

关键词：

D O I：

10.1176/appi.psy.43.6.502

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Triptans are potent serotonin (5-HT) 1B/1D receptor agonists used to abort and treat migraine headaches. Although the triptans share pharmacodynamic characteristics at 5-HT1B/1D receptors, they differ pharmacokinetically. This coulmn reviews how the triptans are metabolized. Generally the triptans are metabolized by phase 1 monoamine oxidases (MAOs) and by various cytochrome P450 enzymes. However, each triptan has a unique metabolic profile, leading to significant differences in each triptan's potential for drug-drug interactions. These differences are detailed in this review.

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收藏

页码：502 / 504

页数：3

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