Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection

被引：246

作者：

Pearson, JP

Feldman, M

Iglewski, BH

Prince, A

机构：

[1] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA

[2] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 07期

关键词：

D O I：

10.1128/IAI.68.7.4331-4334.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell to cell signaling controls many virulence genes in Pseudomonas aeruginosa. We tested the virulence of las acid rhl quorum-sensing mutants in neonatal mice. A lasI rhlI double mutant was nearly avirulent, and the respective single mutant strains were reduced in virulence compared with the wild-type strain. Quorum sensing plays a role in P, aeruginosa pneumonia in neonatal mice.

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页码：4331 / 4334

页数：4

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