Total Synthesis of Aigialomycin D using a One-Pot Ketene Generation-Trapping-Aromatization Sequence

被引：56

作者：

Calo, Frederick ^{[1
]}

Richardson, Jeffery ^{[2
]}

Barrett, Anthony G. M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Eli Lilly & Co Ltd, Windlesham GU20 6PH, Surrey, England

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 21期

基金：

英国工程与自然科学研究理事会;

关键词：

ENANTIOSELECTIVE TOTAL-SYNTHESIS; RING-CLOSING METATHESIS; NATURAL-PRODUCTS; ACID; MACROCYCLIZATION;

D O I：

10.1021/ol901979x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of aigialomycin D, without the need for phenol protection, was carried out using the C-acylation of a keto-dioxinone dianion, a cascade sequence consisting of ketene generation, alcohol trapping and aromatization, and ring-closing metathesis.

引用

页码：4910 / 4913

页数：4

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