Homologues and isomers of noladin ether, a putative novel endocannabinoid:: Interaction with rat cannabinoid CB1 receptors

被引：5

作者：

Appendino, G

Ligresti, A

Minassi, A

Daddario, N

Bisogno, T

Di Marzo, V

机构：

[1] DiSCAFF, I-28100 Novara, Italy

[2] CNR, Ist Chim Biomol, Endocannabinoid Res Grp, I-80078 Pozzuoli, NA, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(02)00839-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB1 receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB1 receptors. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：43 / 46

页数：4

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