The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

被引：575

作者：

Zingaretti, Maria Cristina ^{[1
]}

Crosta, Francesca ^{[2
]}

Vitali, Alessandra ^{[1
]}

Guerrieri, Mario ^{[2
]}

Frontini, Andrea ^{[1
]}

Cannon, Barbara ^{[3
]}

Nedergaard, Jan ^{[3
]}

Cinti, Saverio ^{[1
]}

机构：

[1] Univ Ancona, Osped Riuniti Ancona, Dept Mol Pathol & Innovat Therapies, Politecn Marche,Fac Med, IT-60020 Ancona, Italy

[2] Univ Ancona, Osped Riuniti Ancona, Clin Chirurg Gen & Metodol Chirurg, Politecn Marche, IT-60020 Ancona, Italy

[3] Stockholm Univ, Dept Physiol, Wenner Gren Inst, Arrhenius Labs F3, S-10691 Stockholm, Sweden

来源：

FASEB JOURNAL | 2009年 / 23卷 / 09期

基金：

瑞典研究理事会;

关键词：

uncoupling protein; obesity; sympathetic nervous system; tyrosine hydroxylase immunoreactivity; capillaries; precursor cells; THERMOGENESIS; PROPRANOLOL;

D O I：

10.1096/fj.09-133546

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Classically, adult humans have been considered not to possess active brown adipose tissue ( BAT). However, positron-emission-tomography has shown fluorodeoxyglucose uptake that is distributed in such a way (e.g., in the neck) that it would seem to be BAT. Until now this has not been supported by direct evidence that these areas truly represented BAT, that is, the presence of the BAT-unique uncoupling protein-1 (UCP1). Samples of adipose tissue from the neck of 35 patients undergoing surgery for thyroid diseases were obtained and analyzed. In 1/3 of the subjects ( the younger and leaner), distinct islands composed of UCP1 immunoreactive brown adipocytes could clearly be discerned, accounting for up to 1/3 of all adipocytes. The brown-adipose islands were richly sympathetically innervated ( indicating acute central control); adjacent white adipose areas were not. The capillary density was high, implying a high capacity for oxygen delivery. Cells with features of brown adipocyte precursors were found in pericapillary areas. These data demonstrate that human adults indeed possess BAT and thus imply possibilities of future therapeutic strategies for the treatment of obesity, including maintenance of brown adipocytes and stimulation of the growth of preexisting brown precursors.-Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., Cinti, S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 23, 3113-3120 ( 2009). www.fasebj.org

引用

页码：3113 / 3120

页数：8

共 16 条

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