Take care of your chromosomes lest cancer takes care of you

被引：26

作者：

Maser, RS ^{[1
]}

DePinho, RA

机构：

[1] Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

CANCER CELL | 2003年 / 3卷 / 01期

关键词：

D O I：

10.1016/S1535-6108(02)00243-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The analysis of compound mouse mutants for nonhomologous end-joining DNA double-strand break repair and those deficient for the p53 checkpoint pathway has provided a fascinating look at the carcinogenic consequences of the failure to properly repair DNA damage and to elicit appropriate checkpoints.

引用

页码：4 / 6

页数：3

共 15 条

[1] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[2] DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes [J].

Bailey, SM ;

Meyne, J ;

Chen, DJ ;

Kurimasa, A ;

Li, GC ;

Lehnert, BE ;

Goodwin, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :14899-14904

[3] p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis [J].

Chin, L ;

Artandi, SE ;

Shen, Q ;

Tam, A ;

Lee, SL ;

Gottlieb, GJ ;

Greider, CW ;

DePinho, RA .

CELL, 1999, 97 (04) :527-538

[4] Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells [J].

di Fagagna, FD ;

Hande, MP ;

Tong, WM ;

Roth, D ;

Lansdorp, PM ;

Wang, ZQ ;

Jackson, SP .

CURRENT BIOLOGY, 2001, 11 (15) :1192-1196

[5] Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification [J].

Difilippantonio, MJ ;

Petersen, S ;

Chen, HT ;

Johnson, R ;

Jasin, M ;

Kanaar, R ;

Ried, T ;

Nussenzweig, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (04) :469-480

[6] DNA double strand break repair and chromosomal translocation: Lessons from animal models [J].

Ferguson, DO ;

Alt, FW .

ONCOGENE, 2001, 20 (40) :5572-5579

[7] The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice [J].

Gladdy, RA ;

Taylor, MD ;

Williams, CJ ;

Grandal, I ;

Karaskova, J ;

Squire, JA ;

Rutka, JT ;

Guidos, CJ ;

Danska, JS .

CANCER CELL, 2003, 3 (01) :37-50

[8] Animal models of tumor-suppressor genes [J].

Hakem, R ;

Mak, TW .

ANNUAL REVIEW OF GENETICS, 2001, 35 :209-241

[9] Genetic instabilities in human cancers [J].

Lengauer, C ;

Kinzler, KW ;

Vogelstein, B .

NATURE, 1998, 396 (6712) :643-649

[10] Debate surges over the origins of genomic defects in cancer [J].

Marx, J .

SCIENCE, 2002, 297 (5581) :544-546

← 1 2 →