Selective N-demethylation of galanthamine to norgalanthamine via a non classical Polonovski reaction

被引：42

作者：

Mary, A ^{[1
]}

Renko, DZ ^{[1
]}

Guillou, C ^{[1
]}

Thal, C ^{[1
]}

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(97)01097-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The previously unknown N-demethylation of galanthamine 1 to norgalanthamine 3 was selectively accomplished by a non classical Polonovski reaction using iron salts. This transformation constitutes the first example of the application of the Polonovski reaction to an N-oxide of a seven membered cyclic amine. Norgalanthamine is a valuable intermediate in new galanthamine derivatives synthesis. (C) 1997 Published by Elsevier Science Ltd.

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页码：5151 / 5152

页数：2

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