Allelic distribution of CCR5 and CCR2 genes in an Italian population sample

被引：17

作者：

Romano-Spica, V

Ianni, A

Arzani, D

Cattarini, L

Majore, S

Dean, M

机构：

[1] Catholic Univ, Fac Med, Inst Hyg & Publ Hlth, I-00168 Rome, Italy

[2] Univ Rome La Sapienza, Fac Med, Inst Med Genet, Rome, Italy

[3] NCI, Lab Genomic Divers, Frederick, MD 21702 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2000年 / 16卷 / 02期

关键词：

D O I：

10.1089/088922200309430

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genetic polymorphisms of CCR5 and CCR2 human chemokine receptors have been associated with resistance during HIV-1 infection and disease progression. The protective effect of mutant alleles at these loci has important implications: in AIDS pathogenesis. Chemokine receptors have a role in viral entry into target cells as well as in immune response modulation. In the present report, me studied the frequency of CCR5 Delta 32 and CCR264I allelic variants among a representative sample of the Italian population. Observed allelic frequencies were 0.0454 and 0.0655, respectively. In both cases, genotype distribution was in equilibrium as predicted by the Hardy-Weinberg equation. Taken as a whole, about 21% of the population sample was found to be heterozygous for one or another of those two mutated alleles, Distribution of CCR5 Delta 32 and CCR264I allelic variants within a population can be considered as a measure of genetic susceptibility to HIV infection and disease progression.

引用

页码：99 / 101

页数：3

共 28 条

[1]

ALKHATIB G, 1996, SCIENCE, V272, P1995

[2]

Ausubel FM., 1998, CURRENT PROTOCOLS MO

[3] HIV-1 infection in an individual homozygous for the CCR5 deletion allele [J].

Biti, R ;

French, RF ;

Young, J ;

Bennetts, B ;

Stewart, G ;

Liang, T .

NATURE MEDICINE, 1997, 3 (03) :252-253

[4] The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates [J].

Choe, H ;

Farzan, M ;

Sun, Y ;

Sullivan, N ;

Rollins, B ;

Ponath, PD ;

Wu, LJ ;

Mackay, CR ;

LaRosa, G ;

Newman, W ;

Gerard, N ;

Gerard, C ;

Sodroski, J .

CELL, 1996, 85 (07) :1135-1148

[5] Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene [J].

Dean, M ;

Carrington, M ;

Winkler, C ;

Huttley, GA ;

Smith, MW ;

Allikmets, R ;

Goedert, JJ ;

Buchbinder, SP ;

Vittinghoff, E ;

Gomperts, E ;

Donfield, S ;

Vlahov, D ;

Kaslow, R ;

Saah, A ;

Rinaldo, C ;

Detels, R ;

OBrien, SJ .

SCIENCE, 1996, 273 (5283) :1856-1862

[6] Identification of a major co-receptor for primary isolates of HIV-1 [J].

Deng, HK ;

Liu, R ;

Ellmeier, W ;

Choe, S ;

Unutmaz, D ;

Burkhart, M ;

DiMarzio, P ;

Marmon, S ;

Sutton, RE ;

Hill, CM ;

Davis, CB ;

Peiper, SC ;

Schall, TJ ;

Littman, DR ;

Landau, NR .

NATURE, 1996, 381 (6584) :661-666

[7] A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors [J].

Doranz, BJ ;

Rucker, J ;

Yi, YJ ;

Smyth, RJ ;

Samson, M ;

Peiper, SC ;

Parmentier, M ;

Collman, RG ;

Doms, RW .

CELL, 1996, 85 (07) :1149-1158

[8] Chemokine receptors as fusion cofactors for human immunodeficiency virus type 1 (HIV-1) [J].

Doranz, BJ ;

Berson, JF ;

Rucker, J ;

Doms, RW .

IMMUNOLOGIC RESEARCH, 1997, 16 (01) :15-28

[9] HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5 [J].

Dragic, T ;

Litwin, V ;

Allaway, GP ;

Martin, SR ;

Huang, YX ;

Nagashima, KA ;

Cayanan, C ;

Maddon, PJ ;

Koup, RA ;

Moore, JP ;

Paxton, WA .

NATURE, 1996, 381 (6584) :667-673

[10] Chemokine receptor CCR2b 64I polymorphism and its relation to CD4 T-cell counts and disease progression in a Danish cohort of HIV-infected individuals [J].

Eugen-Olsen, J ;

Iversen, AKN ;

Benfield, TL ;

Koppelhus, U ;

Garred, P .

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1998, 18 (02) :110-116

← 1 2 3 →