A cytotoxic neolignan from Schisandra propinqua (Wall.) Baill.

被引：27

作者：

Xu, Li-Jia

Huang, Feng

Chen, Si-Bao

Li, Lian-Niang

Chen, Shi-Lin ^{[1
]}

Xiao, Pei-Gen

机构：

[1] Peking Union Med Coll, Inst Med Plant Dev, Beijing 100094, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100094, Peoples R China

[3] State Key Lab Chinese Med & Mol Pharmacol, Shenzhen 518057, Peoples R China

[4] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

[5] Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China

[6] Chinese Acad Med Sci, Beijing 100050, Peoples R China

来源：

JOURNAL OF INTEGRATIVE PLANT BIOLOGY | 2006年 / 48卷 / 12期

关键词：

cytotoxicity; lignan; Schisandra propinqua; Schisandraceae;

D O I：

10.1111/j.1744-7909.2006.00323.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In the course of our study of bioactive natural products from Schisandra plants, we isolated a neolignan from an EtOAc extract of the stems of Schisandra propinqua (Wall.) Baill. The structure of the new compound was determined to be 4, 4-di (4-hydroxy-3-methoxyphenly)-2, 3-climethylbutanol (compound 1) on the basis of H-1- and C-13-NMR spectra and 2D NMR methods. Eight known compounds, compounds 2-9, were also isolated and identified, of which compounds 3, 4, 6 and 9 were isolated for the first time from this plant. In addition, compounds 1-4 were evaluated for cytotoxicity by an 3-(4,5-dimethyl-2 thiazoyl)-2,5-dlphenyl-2H-tetrazolium bromide (MTT) assay. Compound 1 showed significant potential cytotoxic ability in the bioassay.

引用

页码：1493 / 1497

页数：5

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