An efficient synthesis of 4-alkenyl/alkynyl-6-methyl-2-pyrones via Pd-catalysed coupling on 4-bromo-6-methyl-2-pyrone

被引:58
作者
Marrison, LR [1 ]
Dickinson, JM [1 ]
Ahmed, R [1 ]
Fairlamb, IJS [1 ]
机构
[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England
基金
英国工程与自然科学研究理事会;
关键词
D O I
10.1016/S0040-4039(02)02207-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
We herein report the efficient syntheses of biologically active 4-alkenyl- and 4-alkynyl-6-methyl-2-pyrones using Pd-catalysed coupling procedures. A palladium on carbon/triphenylphosphine combination is shown to be the most effective catalyst for Sonogashira cross-coupling of several terminal acetylenes with 4-bromo-6-methyl-2-pyrone in yields of up to 95%. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:8853 / 8857
页数:5
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