Fractional crystallisation of (±)-iso-amarine with mandelic acid:: convenient access to (R,R)- and (S,S)-1,2-diamino-1,2-diphenylethanes

被引：15

作者：

Braddock, D. Christopher ^{[1
]}

Hermitage, Stephen A.

Redmond, Joanna M.

White, Andrew J. P.

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] GlaxoSmithKline Inc, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 20期

关键词：

D O I：

10.1016/j.tetasy.2006.10.044

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(+/-)-iso-Amarine can be conveniently resolved via 1:1 salt formation with either hand of mandelic acid. Enantiopure iso-amarine can be acetylated and hydrolysed to give enantiopure 1,2-diamino-1,2-diphenylethanes. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2935 / 2937

页数：3

共 6 条

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