Vascularity, angiogenesis and angiogenic factors in leukemias and myelodysplastic syndromes

被引:37
作者
Aguayo, A [1 ]
Giles, F [1 ]
Albitar, M [1 ]
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA
关键词
VEGF; bFGF; HGF; TNF-alpha; leukemia; vascularity;
D O I
10.1080/1042819021000029777
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Bone marrow microenvironment plays a crucial role in the leukemogenic process. New studies suggest that the bone marrow vascularity changes significantly in the leukemic process and that angiogenic factors play a major role in leukemia and myelodysplasia. However, hematologic malignancies appear to be particularly vulnerable to the effects of angiogenic factors because most of these factors appear to be secreted by hematopoietic cells, and they may have autocrine and paracrine regulatory effects on the hematopoietic system. The use of angiogenesis inhibitors for the treatment of hematologic malignancies is particularly attractive because it may target not only the environment but also the malignant cells.
引用
收藏
页码:213 / 222
页数:10
相关论文
共 147 条
[1]  
ABBOUD C, 1995, HEMATOLOGY
[2]   Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes [J].
Aguayo, A ;
Kantarjian, H ;
Manshouri, T ;
Gidel, C ;
Estey, E ;
Thomas, D ;
Koller, C ;
Estrov, Z ;
O'Brien, S ;
Keating, M ;
Freireich, E ;
Albitar, M .
BLOOD, 2000, 96 (06) :2240-2245
[3]   Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia [J].
Aguayo, A ;
Estey, E ;
Kantarjian, H ;
Mansouri, T ;
Gidel, C ;
Keating, M ;
Giles, F ;
Estrov, Z ;
Barlogie, B ;
Albitar, M .
BLOOD, 1999, 94 (11) :3717-3721
[4]  
Aguayo A, 1998, BLOOD, V92, p226A
[5]   Clinical relevance of Flt1 and Tie1 angiogenesis receptors expression in B-cell chronic lymphocytic leukemia (CLL) [J].
Aguayo, A ;
Manshouri, T ;
O'Brien, S ;
Keating, M ;
Beran, M ;
Koller, C ;
Kantarjian, H ;
Rogers, A ;
Albitar, M .
LEUKEMIA RESEARCH, 2001, 25 (04) :279-285
[6]  
Ahmed A, 1997, LAB INVEST, V76, P779
[7]   VASCULAR REACTIONS OF NORMAL AND MALIGNANT TISSUES INVIVO .1. VASCULAR REACTIONS OF MICE TO WOUNDS AND TO NORMAL AND NEOPLASTIC TRANSPLANTS [J].
ALGIRE, GH ;
CHALKLEY, HW .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1945, 6 (01) :73-85
[8]   Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer [J].
Anan, K ;
Morisaki, T ;
Katano, M ;
Ikubo, A ;
Kitsuki, H ;
Uchiyama, A ;
Kuroki, S ;
Tanaka, M ;
Torisu, M .
SURGERY, 1996, 119 (03) :333-339
[9]  
ARMSTRONG E, 1993, LEUKEMIA, V7, P1585
[10]  
Badet J, 1999, PATHOL BIOL, V47, P345