Suicide genes: past, present and future perspectives

被引：58

作者：

Lal, S ^{[1
]}

Lauer, UM

Niethammer, D

Beck, JF

Schlegel, PG

机构：

[1] Univ Tubingen, Childrens Hosp, Dept Paediat Haematol & Oncol, D-72076 Tubingen, Germany

[2] Univ Tubingen, Dept Internal Med, D-72076 Tubingen, Germany

[3] Univ Greifswald, Childrens Hosp, D-17487 Greifswald, Germany

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 01期

关键词：

D O I：

10.1016/S0167-5699(99)01550-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Disappointing morbidity nd mortality rates in many disorders have necessitated the development of several 'biological' therapies. Once approach involves the use of suicide genes, Here, Shangara Lal and colleagues discuss the development of this branch of gene therapy in cell lines and animal models, and examine current studies, therapeutic applications and clinical trials.

引用

页码：48 / 54

页数：7

共 47 条

[1] APOSHIAN HV, 1972, FED PROC, V31, P1310
[2] AUSTIN EA, 1993, MOL PHARMACOL, V43, P380
[3] SEMLIKI FOREST VIRUS EXPRESSION SYSTEM - PRODUCTION OF CONDITIONALLY INFECTIOUS RECOMBINANT PARTICLES
BERGLUND, P
SJOBERG, M
GAROFF, H
ATKINS, GJ
SHEAHAN, BJ
LILJESTROM, P
[J]. BIO-TECHNOLOGY, 1993, 11 (08): : 916 - 920
[4] Blomer U, 1997, J VIROL, V71, P6641
[5] HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia
Bonini, C
Ferrari, G
Verzeletti, S
Servida, P
Zappone, E
Ruggieri, L
Ponzoni, M
Rossini, S
Mavilio, F
Traversari, C
Bordignon, C
[J]. SCIENCE, 1997, 276 (5319) : 1719 - 1724
[6] TRANSFER OF THE HSV-TK GENE INTO DONOR PERIPHERAL-BLOOD LYMPHOCYTES FOR IN-VIVO MODULATION OF DONOR ANTITUMOR IMMUNITY AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION
BORDIGNON, C
BONINI, C
VERZELETTI, S
NOBILI, N
MAGGIONI, D
TRAVERSARI, C
GIAVAZZI, R
SERVIDA, P
ZAPPONE, E
BENAZZI, E
BERNARDI, M
PORTA, F
FERRARI, G
MAVILIO, F
ROSSINI, S
BLAESE, RM
CANDOTTI, F
[J]. HUMAN GENE THERAPY, 1995, 6 (06) : 813 - 819
[7] VESICULAR STOMATITIS-VIRUS G GLYCOPROTEIN PSEUDOTYPED RETROVIRAL VECTORS - CONCENTRATION TO VERY HIGH-TITER AND EFFICIENT GENE-TRANSFER INTO MAMMALIAN AND NONMAMMALIAN CELLS
BURNS, JC
FRIEDMANN, T
DRIEVER, W
BURRASCANO, M
YEE, JK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) : 8033 - 8037
[8] Persistence in muscle of an adenoviral vector that lacks all viral genes
Chen, HH
Mack, LM
Kelly, R
Ontell, M
Kochanek, S
Clemens, PR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) : 1645 - 1650
[9] Chen L, 1996, CANCER RES, V56, P1331
[10] COMBINATION GENE-THERAPY FOR LIVER METASTASIS OF COLON-CARCINOMA IN-VIVO
CHEN, SH
CHEN, XHL
WANG, TB
KOSAI, KI
FINEGOLD, MJ
RICH, SS
WOO, SLC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) : 2577 - 2581

← 1 2 3 4 5 →