Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine

被引：36

作者：

Huang, FL ^{[1
]}

Li, YY ^{[1
]}

Yu, JQ ^{[1
]}

Spencer, JB ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge Ctr Mol Recognit, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 23期

关键词：

D O I：

10.1039/b209799k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The gene btrR from Bacillus circulans has been cloned and expressed and shown to produce a protein which catalyses the transamination of 2-deoxy-scyllo-inosose to give 2-deoxy-scyllo-inosamine, an intermediate in the biosynthesis of 2-deoxystreptamine.

引用

页码：2860 / 2861

页数：2

共 11 条

[1] Identification of stsC, the gene encoding the L-glutamine:scyllo-inosose aminotransferase from streptomycin-producing Streptomycetes [J].

Ahlert, J ;

Distler, J ;

Mansouri, K ;

Piepersberg, W .

ARCHIVES OF MICROBIOLOGY, 1997, 168 (02) :102-113

[2] STREPTOMYCIN BIOSYNTHESIS AND ITS REGULATION IN STREPTOMYCETES [J].

DISTLER, J ;

MANSOURI, K ;

MAYER, G ;

STOCKMANN, M ;

PIEPERSBERG, W .

GENE, 1992, 115 (1-2) :105-111

[3] BIOSYNTHESIS OF BUTIROSINS .2. BIOSYNTHETIC-PATHWAY OF BUTIROSINS ELUCIDATED FROM CO-SYNTHESIS AND FEEDING EXPERIMENTS [J].

FURUMAI, T ;

TAKEDA, K ;

KINUMAKI, A ;

ITO, Y ;

OKUDA, T .

JOURNAL OF ANTIBIOTICS, 1979, 32 (09) :891-899

[4] Biochemical studies on 2-deoxy-scyllo-inosose -: Part VII -: Substrate specificity of 2-deoxy-scyllo-inosose synthase, the starter enzyme for 2-deoxystreptamine biosynthesis, toward deoxyglucose-6-phosphates and proposed mechanism [J].

Iwase, N ;

Kudo, F ;

Yamauchi, N ;

Kakinuma, K .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1998, 62 (12) :2396-2407

[5] Kinetic isotope effect and reaction mechanism of 2-deoxy-scyllo-inosose synthase derived from butirosin-producing Bacillus circulans [J].

Kudo, F ;

Yamauchi, N ;

Suzuki, R ;

Kakinuma, K .

JOURNAL OF ANTIBIOTICS, 1997, 50 (05) :424-428

[6] Molecular cloning of the gene for the key carbocycle-forming enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics and its comparison with dehydroquinate synthase [J].

Kudo, F ;

Tamegai, H ;

Fujiwara, T ;

Tagami, U ;

Hirayama, K ;

Kakinuma, K .

JOURNAL OF ANTIBIOTICS, 1999, 52 (06) :559-571

[7] Butirosin-biosynthetic gene cluster from Bacillus circulans [J].

Ota, Y ;

Tamegai, H ;

Kudo, F ;

Kuriki, H ;

Koike-Takeshita, A ;

Eguchi, T ;

Kakinuma, K .

JOURNAL OF ANTIBIOTICS, 2000, 53 (10) :1158-1167

[8] BIOSYNTHESIS OF AMINOCYCLITOL ANTIBIOTICS [J].

RINEHART, KL ;

STROSHANE, RM .

JOURNAL OF ANTIBIOTICS, 1976, 29 (04) :319-353

[9] BIOSYNTHESIS OF 2-DEOXYSTREPTAMINE [J].

SUZUKAKE, K ;

TOKUNAGA, K ;

HAYASHI, H ;

HORI, M ;

UEHARA, Y ;

IKEDA, D ;

UMEZAWA, H .

JOURNAL OF ANTIBIOTICS, 1985, 38 (09) :1211-1218

[10] ENZYMATIC CARBOCYCLE FORMATION IN MICROBIAL SECONDARY METABOLISM - THE MECHANISM OF THE 2-DEOXY-SCYLLO-INOSOSE SYNTHASE REACTION AS A CRUCIAL STEP IN THE 2-DEOXYSTREPTAMINE BIOSYNTHESIS IN STREPTOMYCES-FRADIAE [J].

YAMAUCHI, N ;

KAKINUMA, K .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (17) :5614-5619

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