Intermolecular Interactions of Sprouty Proteins and Their Implications in Development and Disease

被引：92

作者：

Edwin, Francis ^{[1
]}

Anderson, Kimberly ^{[1
]}

Ying, Chunyi ^{[1
]}

Patel, Tarun B. ^{[1
]}

机构：

[1] Loyola Univ Chicago, Dept Pharmacol & Expt Therapeut, Stritch Sch Med, Maywood, IL 60153 USA

来源：

MOLECULAR PHARMACOLOGY | 2009年 / 76卷 / 04期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR RECEPTOR; HUMAN PROSTATE-CANCER; DOWN-REGULATION; TYROSINE-PHOSPHATASE; TUMOR-SUPPRESSOR; IN-VIVO; BRANCHING MORPHOGENESIS; KIDNEY DEVELOPMENT; GENE-EXPRESSION; ERK ACTIVATION;

D O I：

10.1124/mol.109.055848

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Receptor tyrosine kinase (RTK) signaling is spatially and temporally regulated by a number of positive and negative regulatory mechanisms. These regulatory mechanisms control the amplitude and duration of the signals initiated at the cell surface to have a normal or aberrant biological outcome in development and disease, respectively. In the past decade, the Sprouty (Spry) family of proteins has been identified as modulators of RTK signaling in normal development and disease. This review summarizes recent advances concerning the biological activities modulated by Spry family proteins, their interactions with signaling proteins, and their involvement in cardiovascular diseases and cancer. The diversity of mechanisms in the regulation of Spry expression and activity in cell systems emphasizes the crucial role of Spry proteins in development and growth across the animal kingdom.

引用

页码：679 / 691

页数：13

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