Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon

被引：76

作者：

Borrelli, F

Izzo, AA

Di Carlo, G

Maffia, P

Russo, A

Maiello, FM

Capasso, F

Mascolo, N

机构：

[1] Univ Naples Federico II, Dept Expt Pharmacol, I-80131 Naples, Italy

[2] Univ Catania, Dept Biochem Med Chem & Mol Biol, Catania, Italy

[3] ASL 1 Osped Pellegrini, Dept Diagnost Serv, Anat & Pathol Histol Serv, I-80134 Naples, Italy

来源：

FITOTERAPIA | 2002年 / 73卷

关键词：

propolis; CAPE; tumors; aberrant crypt foci;

D O I：

10.1016/S0367-326X(02)00189-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have studied the effect of propolis and its main active ingredient caffeic acid phenetyl ester (CAPE) on formation of aberrant crypt foci (ACF) and tumors in the rat colon in vivo. CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis. (C) 2002 Elsevier Science B.V. All rights reserved.

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收藏

页码：S38 / S43

页数：6

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