Characterization and optimization of liquid electrodes for lateral dielectrophoresis

被引:118
作者
Demierre, Nicolas [1 ]
Braschler, Thomas [1 ]
Linderholm, Pontus [1 ]
Seger, Urban [1 ]
van Lintel, Harald [1 ]
Renaud, Philippe [1 ]
机构
[1] Ecole Polytech Fed Lausanne, Lab Microsyst, CH-1015 Lausanne, Switzerland
关键词
D O I
10.1039/b612866a
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Using the concept of insulator-based "electrodeless'' dielectrophoresis, we present a novel geometry for shaping electric fields to achieve lateral deviation of particles in liquid flows. The field is generated by lateral planar metal electrodes and is guided along access channels to the active area in the main channel. The equipotential surfaces at the apertures of the access channels behave as vertical "liquid'' electrodes injecting the current into the main channel. The field between a pair of adjacent liquid electrodes generates the lateral dielectrophoretic force necessary for particle manipulation. We use this force for high-speed deviation of particles. By adding a second pair of liquid electrodes, we focus a particle stream. The position of the focused stream can be swept across the channel by adjusting the ratio of the voltages applied to the two pairs. Based on conformal mapping, we provide an analytical model for estimating the potential at the liquid electrodes and the field distribution in the main channel. We show that the simulated particle trajectories agree with observations. Finally, we show that the model can be used to optimize the device geometry in different applications.
引用
收藏
页码:355 / 365
页数:11
相关论文
共 35 条
[1]   SURFACE CONDUCTANCE AND OTHER PROPERTIES OF LATEX-PARTICLES MEASURED BY ELECTROROTATION [J].
ARNOLD, WM ;
SCHWAN, HP ;
ZIMMERMANN, U .
JOURNAL OF PHYSICAL CHEMISTRY, 1987, 91 (19) :5093-5098
[2]   DC-dielectrophoretic separation of microparticles using an oil droplet obstacle [J].
Barbulovic-Nad, I ;
Xuan, XC ;
Lee, JSH ;
Li, DQ .
LAB ON A CHIP, 2006, 6 (02) :274-279
[3]   Dielectrophoretic manipulation of particles and cells using insulating ridges in faceted prism microchannels [J].
Barrett, LM ;
Skulan, AJ ;
Singh, AK ;
Cummings, EB ;
Fiechtner, GJ .
ANALYTICAL CHEMISTRY, 2005, 77 (21) :6798-6804
[4]  
BINNS LJ, 1992, ANAL NUMERICAL SOLUT
[5]   Design and operation of a microfluidic sorter for Drosophila embryos [J].
Chen, CC ;
Zappe, S ;
Sahin, O ;
Zhang, XJ ;
Fish, M ;
Scott, M ;
Solgaard, O .
SENSORS AND ACTUATORS B-CHEMICAL, 2004, 102 (01) :59-66
[6]   Electrodeless dielectrophoresis for micro total analysis systems [J].
Chou, CF ;
Zenhausern, F .
IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, 2003, 22 (06) :62-67
[7]   Electrodeless dielectrophoresis of single- and double-stranded DNA [J].
Chou, CF ;
Tegenfeldt, JO ;
Bakajin, O ;
Chan, SS ;
Cox, EC ;
Darnton, N ;
Duke, T ;
Austin, RH .
BIOPHYSICAL JOURNAL, 2002, 83 (04) :2170-2179
[8]   Cytometry and velocimetry on a microfluidic chip using polyelectrolytic salt bridges [J].
Chun, HG ;
Chung, TD ;
Kim, HC .
ANALYTICAL CHEMISTRY, 2005, 77 (08) :2490-2495
[9]   Microdevices for manipulation and accumulation of micro- and nanoparticles by dielectrophoresis [J].
Dürr, M ;
Kentsch, J ;
Müller, T ;
Schnelle, T ;
Stelzle, M .
ELECTROPHORESIS, 2003, 24 (04) :722-731
[10]   Dielectrophoretic sorting of particles and cells in a microsystem [J].
Fiedler, S ;
Shirley, SG ;
Schnelle, T ;
Fuhr, G .
ANALYTICAL CHEMISTRY, 1998, 70 (09) :1909-1915