Plasma angiotensinogen concentrations in obese patients

被引：137

作者：

Umemura, S ^{[1
]}

Nyui, N ^{[1
]}

Tamura, K ^{[1
]}

Hibi, K ^{[1
]}

Yamaguchi, S ^{[1
]}

Nakamaru, M ^{[1
]}

Ishigami, T ^{[1
]}

Yabana, M ^{[1
]}

Kihara, M ^{[1
]}

Inoue, S ^{[1
]}

Ishii, M ^{[1
]}

机构：

[1] NATL INST NUTR,TOKYO,JAPAN

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1997年 / 10卷 / 06期

关键词：

angiotensinogen; obesity; hypertension; body mass index; blood pressure;

D O I：

10.1016/S0895-7061(97)00053-8

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

A close relationship between obesity and hypertension has been recognized, and plasma angiotensinogen concentrations (p-AGT) have been reported to correlate with blood pressure (BP). However, little is known about AGT in obese patients with hypertension. To define the role of AGT in obese hypertension, we measured p-AGT in obese patients. The subjects were 42 obese patients diagnosed on the basis of a body mass index (BMI) of more than 25 kg/m(2), and 21 sex- and age-matched nonobese patients, whose BMI was less than 25 kg/m(2). The hypertensive patients had not previously received antihypertensive drugs. P-AGT (P<.05) and mean BP (P<.0001) was increased in the obese patients as compared with the nonobese patients. Positive correlations were observed between BMI and p-AGT, mean BP and p-AGT, and BMI and mean BP (all P<.05). However, after adjustment for blood pressure, p-AGT was not different between groups, and after adjustment a positive correlation remained only between BMI and mean BP. These results suggested the possible involvement of increased p-AGT in hypertension in obese patients, although this may be a secondary change to hypertension or obesity. (C) 1997 by the American Journal of Hypertension, Ltd.

引用

页码：629 / 633

页数：5

共 23 条

[1] THE SERUM ANGIOTENSINOGEN CONCENTRATION AND VARIANTS OF THE ANGIOTENSINOGEN GENE IN WHITE AND BLACK-CHILDREN [J].