N-Heterocyclic Carbene-Catalyzed Intramolecular Aldehyde-Nitrile Cross Coupling: An Easy Access to 3-Aminochromones

被引：52

作者：

Vedachalam, Seenuvasan ^{[1
]}

Zeng, Jing ^{[1
]}

Gorityala, Bala Kishan ^{[1
]}

Antonio, Meraldo ^{[1
]}

Liu, Xue-Wei ^{[1
]}

机构：

[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 02期

关键词：

SOLID-PHASE SYNTHESIS; ACTIVATED DOUBLE-BONDS; THIAZOLIUM SALT; BENZOIN CONDENSATION; ANTIRHEUMATIC DRUG; STETTER REACTION; ALPHA; BETA-UNSATURATED ALDEHYDES; NUCLEOPHILIC-ADDITION; BIOLOGICAL EVALUATION; ASYMMETRIC-SYNTHESIS;

D O I：

10.1021/ol9026232

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An immense effort has been made to develop an efficient strategy for the carbon-carbon bond formation between aldehyde and nitrile intramolecularly using an N-heterocyclic carbene catalyst to derive 3-aminochromone derivatives in good to excellent yields (80-95%).

引用

页码：352 / 355

页数：4

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