Antibiotics from microbes: converging to kill

被引:44
作者
Fischbach, Michael A. [1 ,2 ]
机构
[1] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA
关键词
BIOSYNTHETIC GENE-CLUSTER; ISOPENICILLIN-N SYNTHASE; COMPLETE GENOME SEQUENCE; CLAVULANIC ACID; LIPID-II; POSTTRANSLATIONAL MODIFICATIONS; STREPTOMYCES-CLAVULIGERUS; BETA-LACTAMASES; BACTERIA; EVOLUTION;
D O I
10.1016/j.mib.2009.07.002
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
As genetically encoded small molecules, antibiotics are phenotypes that have resulted from mutation and natural selection. Advances in genetics, biochemistry, and bioinformatics have connected hundreds of antibiotics to the gene clusters that encode them, allowing these molecules to be analyzed using the tools of evolutionary biology. This review surveys examples of convergent evolution from microbially produced antibiotics, including the convergence of distinct gene clusters on similar phenotypes and the merger of distinct gene clusters into a single functional unit. Examining antibiotics through an evolutionary lens highlights the versatility of biosynthetic pathways, reveals lessons for combating antibiotic resistance, and provides an entry point for studying the natural roles of these natural products.
引用
收藏
页码:520 / 527
页数:8
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