Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond

被引:60
作者
Kimura, Akinori [1 ,2 ]
机构
[1] Tokyo Med & Dent Univ, Dept Mol Pathogenesis, Med Res Inst, Bunkyo Ku, Tokyo 1138510, Japan
[2] Tokyo Med & Dent Univ, Lab Genome Divers, Grad Sch Biomed Sci, Tokyo 1138510, Japan
基金
日本学术振兴会;
关键词
calcium sensitivity; cardiomyopathy; mutation; stress response; stretch response; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; RIGHT-VENTRICULAR CARDIOMYOPATHY; IDIOPATHIC DILATED CARDIOMYOPATHY; DREIFUSS MUSCULAR-DYSTROPHY; MUSCLE LIM PROTEIN; CARDIAC TROPONIN-I; HEAVY-CHAIN GENE; ANKYRIN REPEAT PROTEIN; B-CRYSTALLIN MUTATION; LAMIN A/C GENE;
D O I
10.1038/jhg.2009.138
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Cardiomyopathy is caused by functional abnormality of cardiac muscle. The functional abnormality involved in its etiology includes both extrinsic and intrinsic factors, and cardiomyopathy caused by the intrinsic factors is called as idiopathic or primary cardiomyopathy. There are several clinical types of primary cardiomyopathy including hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Linkage studies and candidate gene approaches have explored the disease genes for hereditary primary cardiomyopathy. The most notable finding was that mutations in the same disease gene can be found in different clinical types of cardiomyopathy. Functional analyses of disease-related mutations have revealed that characteristic functional alterations are associated with the clinical types, such that increased and decreased Ca(2+) sensitivity due to sarcomere mutations are associated with HCM and DCM, respectively. In addition, our recent studies have suggested that mutations in the Z-disc components found in HCM and DCM may result in increased and decreased stiffness of sarcomere; that is, stiff sarcomere and loose sarcomere, respectively, and hence altered stretch response. More recently, mutations in the components of I region were found in hereditary cardiomyopathy and the functional analyses of the mutations suggested that the altered stress response was associated with cardiomyopathy, further complicating the etiology and pathogenesis. However, elucidation of genetic etiology and functional alterations caused by the mutations shed lights on the new therapeutic approaches to hereditary cardiomyopathy, such that treatment of DCM with a Ca(2+) sensitizer prevented the disease in a mouse model. Journal of Human Genetics (2010) 55, 81-90; doi: 10.1038/jhg. 2009.138; published online 15 January 2010
引用
收藏
页码:81 / 90
页数:10
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