Plasma levels of tumour necrosis factor-α in patients with chronic periodontitis and type 2 diabetes

被引:105
作者
Engebretson, S. [1 ]
Chertog, R.
Nichols, A.
Hey-Hadavi, J.
Celenti, R.
Grbic, J.
机构
[1] SUNY Stony Brook, Sch Dent Med, Dept Periodontol, Stony Brook, NY 11794 USA
[2] Columbia Univ, Coll Dent Med, New York, NY USA
[3] Pfizer Inc, New York, NY USA
关键词
chronic periodontitis; endotoxin; gingival crevicular fluid; human; interleukin-1; beta; plasma; tumor necrosis factor-alpha; type; 2; diabetes;
D O I
10.1111/j.1600-051X.2006.01017.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objectives: Studies suggest that elevated circulating tumour necrosis factor-alpha (TNF-alpha) may contribute to insulin resistance in patients with type 2 diabetes. The source of plasma TNF has been thought to be adipocytes associated with obesity, but inflammation and infection result in TNF-alpha production as well. Methods: We studied 46 patients with type 2 diabetes and chronic periodontitis to determine the relationship between plasma TNF-alpha levels and clinical measures of periodontitis, gingival crevicular fluid (GCF) interleukin-1 beta (IL-1 beta), plasma endotoxin, serum glucose, and glycated haemoglobin (HbA1c). TNF-alpha levels were measured using a high sensitivity enzyme-linked immunosorbent assay. Results: TNF-alpha showed a significant positive correlation with attachment loss (r=0.40, p=0.009), plasma endotoxin (r=0.33, p=0.03), and GCF IL-1 beta (r=0.33, p=0.035), but not probing depth (r=0.28, p=0.07), bleeding on probing (r=0.30, p=0.053), plaque index (r=0.22, p=0.17), serum glucose, HbA1c (r=0.10, p=0.50), or body mass index (r=0.077, p=0.62). A dose-response relationship was observed between periodontitis severity and TNF-alpha (p=0.012). Conclusion: The finding that chronic periodontitis is associated with plasma TNF-alpha levels in subjects with type 2 diabetes supports the hypothesis that periodontal infection and inflammation may contribute to insulin resistance.
引用
收藏
页码:18 / 24
页数:7
相关论文
共 42 条
[1]   CYTOKINES AND DIABETES - THE FINAL STEP - INVOLVEMENT OF TNF-ALPHA IN BOTH TYPE-I AND TYPE-II DIABETES-MELLITUS [J].
ARGILES, JM ;
LOPEZSORIANO, J ;
LOPEZSORIANO, FJ .
HORMONE AND METABOLIC RESEARCH, 1994, 26 (10) :447-449
[2]  
Bertin E, 2000, DIABETES METAB, V26, P178
[3]   Plasma levels of tumor necrosis factor-α, angiotensin II, growth hormone, and IGF-1 are not elevated in insulin-resistant obese individuals with impaired glucose tolerance [J].
Blüher, M ;
Kratzsch, J ;
Paschke, R .
DIABETES CARE, 2001, 24 (02) :328-334
[4]   Systemic inflammatory markers, periodontal diseases, and periodontal infections in an elderly population [J].
Bretz, WA ;
Weyant, RJ ;
Corby, PM ;
Ren, D ;
Weissfeld, L ;
Kritchevsky, SB ;
Harris, T ;
Kurella, M ;
Satterfield, S ;
Visser, M ;
Newman, AB .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2005, 53 (09) :1532-1537
[5]   Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-α.: Effect of weight loss in obese men [J].
Bruun, JM ;
Verdich, C ;
Toubro, S ;
Astrup, A ;
Richelsen, B .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2003, 148 (05) :535-542
[6]   Association between inflammation and insulin resistance in US nondiabetic adults - Results from the Third National Health and Nutrition Examination Survey [J].
Chen, J ;
Wildman, RP ;
Hamm, LL ;
Muntner, P ;
Reynolds, K ;
Whelton, PK ;
He, J .
DIABETES CARE, 2004, 27 (12) :2960-2965
[7]   Factor VIII and other hemostasis variables are related to incident diabetes in adults - The Atherosclerosis Risk in Communities (ARIC) study [J].
Duncan, BB ;
Schmidt, MI ;
Offenbacher, S ;
Wu, KK ;
Savage, PJ ;
Heiss, G .
DIABETES CARE, 1999, 22 (05) :767-772
[8]   Gingival crevicular fluid levels of interleukin-1β and glycemic control in patients with chronic periodontitis and type 2 diabetes [J].
Engebretson, SP ;
Hey-Hadavi, J ;
Ehrhardt, FJ ;
Hsu, D ;
Celenti, RS ;
Grbic, JT ;
Lamster, IB .
JOURNAL OF PERIODONTOLOGY, 2004, 75 (09) :1203-1208
[9]   GCF IL-1β profiles in periodontal disease [J].
Engebretson, SP ;
Grbic, JT ;
Singer, R ;
Lamster, IB .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2002, 29 (01) :48-53
[10]  
EVERETT ED, 1977, MEDICINE, V56, P61