DNA manipulators:: caught in the act

被引：9

作者：

Changela, A ^{[1
]}

Perry, K ^{[1
]}

Taneja, B ^{[1
]}

Mondragón, A ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2003年 / 13卷 / 01期

关键词：

SITE-SPECIFIC RECOMBINATION; GAMMA-DELTA RESOLVASE; CRYSTAL-STRUCTURE; TOPOISOMERASE-I; 3-DIMENSIONAL STRUCTURE; SYNAPTIC COMPLEX; SINGLE-MOLECULE; MECHANISM; JUNCTION; HELICASE;

D O I：

10.1016/S0959-440X(02)00006-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA is a dynamic molecule that undergoes constant changes in the cell through interactions with numerous proteins. Several classes of enzyme are specialized in promoting DNA rearrangements, including site-specific recombinases, DNA helicases, transposases and DNA topoisomerases. Recent structures of protein-DNA reaction intermediates trapped in various states of DNA remodeling, complemented by biochemical and biophysical functional studies, have enhanced our understanding of their respective mechanistic pathways.

引用

页码：15 / 22

页数：8

共 40 条

[1] Crystal structure of the Holliday junction DNA in complex with a single RuvA tetramer [J].

Ariyoshi, M ;

Nishino, T ;

Iwasaki, H ;

Shinagawa, H ;

Morikawa, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (15) :8257-8262

[2] Helicase structure and mechanism [J].

Caruthers, JM ;

McKay, DB .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2002, 12 (01) :123-133

[3] DNA topoisomerases: Structure, function, and mechanism [J].

Champoux, JJ .

ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 :369-413

[4] Crystal structure of a complex of a type IA DNA topoisomerase with a single-stranded DNA molecule [J].

Changela, A ;

DiGate, RJ ;

Mondragón, A .

NATURE, 2001, 411 (6841) :1077-1081

[5] Identification of active site residues in Escherichia coli DNA topoisomerase I [J].

Chen, SJ ;

Wang, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (11) :6050-6056

[6]

Chen Y, 2000, MOL CELL, V6, P885, DOI 10.1016/S1097-2765(05)00088-2

[7] Preferential relaxation of positively supercoiled DNA by E-coli topoisomerase IV in single-molecule and ensemble measurements [J].

Crisona, NJ ;

Strick, TR ;

Bensimon, D ;

Croquette, V ;

Cozzarelli, NR .

GENES & DEVELOPMENT, 2000, 14 (22) :2881-2892

[8] Three-dimensional structure of the Tn5 synaptic complex transposition intermediate [J].

Davies, DR ;

Goryshin, IY ;

Reznikoff, WS ;

Rayment, I .

SCIENCE, 2000, 289 (5476) :77-85

[9] The mechanism of type IA topoisomerases [J].

Dekker, NH ;

Rybenkov, VV ;

Duguet, M ;

Crisona, NJ ;

Cozzarelli, NR ;

Bensimon, D ;

Croquette, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (19) :12126-12131

[10] Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: Measurement of step size and translocation speed [J].

Dillingham, MS ;

Wigley, DB ;

Webb, MR .

BIOCHEMISTRY, 2000, 39 (01) :205-212

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