Synthesis of highly fluorinated dipeptide building blocks

被引：16

作者：

Koksch, B

Mütze, K

Osipov, SN

Golubev, AS

Burger, K

机构：

[1] Univ Leipzig, Dept Organ Chem, D-04103 Leipzig, Germany

[2] Russian Acad Sci, Inst Organoelement Cpds, Moscow 117813, Russia

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 20期

关键词：

N-acylimines; isocyanides; 4+1]-cycloaddition; alpha-trifluoromethyl alpha-amino acid;

D O I：

10.1016/S0040-4039(00)00540-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach to the synthesis of dipeptides containing up to three trifluoromethyl groups has been developed. The method is based on a [4+1]-cycloaddition reaction of hexafluoroacetone or methyl 3,3,3-trifluoropyruvate derived N-acylimines and alpha-amino acid isocyanides. Acidic hydrolysis of the cycloadducts gives the trifluoromethylated dipeptides in good yields. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3825 / 3828

页数：4

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