Signal transduction of sphingosine-1-phosphate G protein-coupled receptors

被引：57

作者：

Young, Nicholas

Van Brocklyn, James R. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA

[2] Ohio State Univ, Integrated Biomed Sci Grad Program, Columbus, OH 43210 USA

来源：

THESCIENTIFICWORLDJOURNAL | 2006年 / 6卷

关键词：

sphingosine-1-phosphate; S1P; EDG; cell proliferation; cell migration; angiogenesis; lymphocyte trafficking; cancer;

D O I：

10.1100/tsw.2006.182

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 [工学]; 0830 [环境科学与工程];

摘要：

Sphingosine-1-phosphate (S1P) is a bioactive lipid capable of eliciting dramatic effects in a variety of cell types. Signaling by this molecule is by a family of five G protein-coupled receptors named S1P1-5 that signal through a variety of pathways to regulate cell proliferation, migration, cytoskeletal organization, and differentiation. These receptors are expressed in a wide variety of tissues and cell types, and their cellular effects contribute to important biological and pathological functions of S1P in many processes, including angiogenesis, vascular development, lymphocyte trafficking, and cancer. This review will focus on the current progress in the field of S1P receptor signaling and biology.

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收藏

页码：946 / 966

页数：21

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