Stem cell antigen 2 expression in adult and developing mice

被引：30

作者：

Antica, M

Wu, L

Scollay, R

机构：

[1] WALTER & ELIZA HALL INST MED RES,MELBOURNE 3050,AUSTRALIA

[2] CENTENARY INST CELL BIOL & CANC RES,SYDNEY,NSW 2042,AUSTRALIA

来源：

IMMUNOLOGY LETTERS | 1997年 / 55卷 / 01期

关键词：

development; Sca-2/TSA-1; antigen; stem cells; T-lymphocytes;

D O I：

10.1016/S0165-2478(96)02682-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stem cell antigen 2 (Sca-2) expression can distinguish the most immature T-lymphocyte precursors in the thymus from the hemopoietic stem cells. Sequence analysis of the Sca-2 protein showed that Sca-2 is a glycosylphosphatidylinositol (GPI) anchored molecule that shares some characteristics with the members of the Ly-6 multigene family, and that it is the same as the thymic shared antigen-1 (TSA-1). Here we extend these studies and critically reassess the expression of the Sca-2/TSA-1 antigen in hematopoietic tissues of adult and developing mice. With more sensitive methods we show that the distribution of Sca-2/TSA-1 differs from existing reports. We find especially high expression of Sca-2/TSA1 at day 14 of fetal development. (C) 1997 Elsevier Science B.V.

引用

页码：47 / 51

页数：5

共 22 条

[1] AN ATTEMPT TO PRODUCE PRE-T CELL HYBRIDOMAS AND TO IDENTIFY THEIR ANTIGENS [J].