The exocyst complex in polarized exocytosis

被引：332

作者：

He, Bing ^{[1
]}

Guo, Wei ^{[1
]}

机构：

[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 04期

基金：

美国国家卫生研究院;

关键词：

PLASMA-MEMBRANE; SACCHAROMYCES-CEREVISIAE; CRYSTAL-STRUCTURE; SEC6/8; COMPLEX; YEAST; INTERACTS; GTPASE; SNARE; EFFECTOR; SUBUNIT;

D O I：

10.1016/j.ceb.2009.04.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The exocyst is an octameric protein complex, which mediates the tethering of post-Golgi secretory vesicles to the plasma membrane before exocytic fusion. The exocyst assembles by side-by-side packing of rod-shaped subunits composed of helical bundles. The targeting of secretory vesicles to the plasma membrane involves direct interactions of the exocyst with PI(4,5)P-2. In addition, a number of small GTP-binding proteins interact with components of the exocyst and regulate the assembly, localization, and function of this complex. Here we review the recent advances in the field, focusing on the function of the exocyst in polarized exocytosis.

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收藏

页码：537 / 542

页数：6

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