TET2 mutations in myelodysplasia and myeloid malignancies

被引：51

作者：

Mullighan, Charles G. ^{[1
]}

机构：

[1] St Judes Res Hosp, Dept Pathol, Memphis, TN USA

来源：

NATURE GENETICS | 2009年 / 41卷 / 07期

关键词：

LEUKEMIA;

D O I：

10.1038/ng0709-766

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genetic basis of myelodysplasia has long been enigmatic, with few common targets of mutation known. a new study reports common mutations in the TET2 gene in myelodysplasia and related myeloid malignancies, suggesting that TET2 has an important role in hematopoiesis and in the pathogenesis of this disease.

引用

页码：766 / 767

页数：3

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