Overnight suppression of parathyroid hormone and bone resorption markers by active absorbable algae calcium. A double-blind crossover study

被引:13
作者
Fujita, T
Ohgitani, S
Fujii, Y
机构
[1] Calcium Research Institute, Kishiwada, Osaka 596
[2] Department of Clinical Laboratories, Natl. Sanatorium Hyogo Chuo Hospital, Hyogo
关键词
active absorbable algae calcium; parathyroid hormone; cross-linked collagen degradation product (Crosslaps); circadian rhythm;
D O I
10.1007/s002239900272
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In order to study the effect of Ca supplementation on the nocturnal rise of PTH and bone resorption, a double-blind, placebo-controlled study was carried out on 9 healthy male volunteers. Regimen A consisted of an oral dose of 150 mg Ca as AAACa after each meal and 450 mg at bedtime; B consisted of 300 mg after each meal and C was placebo. Plasma ionized Ca was significantly higher in A than in B at 6 a.m. the next morning and urinary Ca/Cr after 5 days was higher in A than in B and C. Plasma intact PTH fell by 19 +/- 4 pg/ml in A, 8 +/- 7 in B, and 1 +/- 7 after 1 day, and significantly decreased by 29 +/- 8 in A, increased by 11 +/- 11 in B, and 5 +/- 7 in C after 5 days (A and B, and A and C, p = 0.0242 and 0.0433, respectively), with increases of % tubular reabsorption of phosphorus. Urinary excretion of cross-linked collagen degradation product (Crosslaps) was 40 +/- 10% of the baseline in A, 97 +/- 22 in B, and 173 +/- 30 in C (A and C, P = 0.0061) after 5 days. Systolic blood pressure at 6 a.m. fell by 17 +/- 4 mmHg A, 24 +/- 3 in B, and 4 +/- 2 in C. Highly biologically available AAACa effectively suppressed nocturnal rise of PTH and bone resorption markers in 5 days.
引用
收藏
页码:506 / 512
页数:7
相关论文
共 23 条
[1]  
BLUMSOHN A, 1995, CHALL MOD MED, V7, P273
[2]  
BONDE M, 1994, CLIN CHEM, V40, P2022
[3]   A CONTROLLED TRIAL OF THE EFFECT OF CALCIUM SUPPLEMENTATION ON BONE-DENSITY IN POSTMENOPAUSAL WOMEN [J].
DAWSONHUGHES, B ;
DALLAL, GE ;
KRALL, EA ;
SADOWSKI, L ;
SAHYOUN, N ;
TANNENBAUM, S .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (13) :878-883
[4]   ENZYMIC DETERMINATION OF INORGANIC PHOSPHATES, ORGANIC-PHOSPHATES AND PHOSPHATE-LIBERATING ENZYMES BY USE OF NUCLEOSIDE PHOSPHORYLASE XANTHINE-OXIDASE (DEHYDROGENASE)-COUPLED REACTIONS [J].
DEGROOT, H ;
DEGROOT, H ;
NOLL, T .
BIOCHEMICAL JOURNAL, 1985, 230 (01) :255-260
[5]   INCREASE OF BONE-MINERAL DENSITY BY CALCIUM SUPPLEMENT WITH OYSTER SHELL ELECTROLYSATE [J].
FUJITA, T ;
FUKASE, M ;
MIYAMOTO, H ;
MATSUMOTO, T ;
OHUE, T .
BONE AND MINERAL, 1990, 11 (01) :85-91
[6]  
Fujita T, 1996, CALCIFIED TISSUE INT, V58, P226
[7]  
FUJITA T, 1988, BONE MINER, V4, P321
[8]  
FUJITA T, 1995, MINER ELECTROL METAB, V21, P229
[9]  
Fujita T., 1995, J BONE MINER METAB, V13, P93
[10]  
Fujita T., 1996, J BONE MINER METAB, V14, P31, DOI [10.1007/BF01771671, DOI 10.1007/BF01771671]