A facile synthesis of 7-amino-3-desacetoxycephalosporanic acid derivatives by indium-mediated reduction of 3-iodomethylcephems in aqueous media

被引：22

作者：

Chae, H ^{[1
]}

Cho, S ^{[1
]}

Keum, G ^{[1
]}

Kang, SB ^{[1
]}

Pae, AN ^{[1
]}

Kim, Y ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Biochem Res Ctr, Seoul 130650, South Korea

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 20期

关键词：

cephalosporin; halogens and compounds; indium and compounds; dehalogenation; water; reactions in;

D O I：

10.1016/S0040-4039(00)00512-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient reductive conversion of 3-iodomethylcephalosporin and 3-acetoxymethylcephalosporin derivatives mediated by indium into the corresponding 3-methylcephems and 3-methylenecephams in moderate to good yields has been developed in an aqueous system. 3-Methylenecephams are converted into the corresponding 3-methylcephems under previously reported basic conditions quantitatively. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3899 / 3901

页数：3

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