Lipid microdomains in cell surface membranes

被引：218

作者：

Edidin, M

机构：

[1] Biology Department, Johns Hopkins Univ., 3400 N C., Baltimore

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(97)80117-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid microdomains within cell membranes are detected by a variety of experimental techniques, each of which characterizes microdomains on a different time and spatial scale. The sum of the data an lipid microdomains has yet to be integrated into a single model of cell membrane structure. Indeed, one highlight of the past year is a new analysis of experimental results which yields a model of a cell membrane which need not contain any microdomains. Other highlights are an estimate of the number of phospholipid molecules in a membrane microdomain and the detection of domain formation in cell membranes in real time. Some progress has also been made in visualizing lipid microdomains within cell membranes. We still await, however, a new model of membrane structure that integrates all experimental results.

引用

收藏

页码：528 / 532

页数：5

相关论文

共 44 条

[1] SORTING OF GPI-ANCHORED PROTEINS TO GLYCOLIPID-ENRICHED MEMBRANE SUBDOMAINS DURING TRANSPORT TO THE APICAL CELL-SURFACE [J].

BROWN, DA ;

ROSE, JK .

CELL, 1992, 68 (03) :533-544

[2] DOES THE BINDING OF CLUSTERS OF BASIC RESIDUES TO ACIDIC LIPIDS INDUCE DOMAIN FORMATION IN MEMBRANES [J].

BUSER, CA ;

KIM, J ;

MCLAUGHLIN, S ;

PEITZSCH, RM .

MOLECULAR MEMBRANE BIOLOGY, 1995, 12 (01) :69-75

[3] Changes in the spectral properties of a plasma membrane lipid analog during the first seconds of endocytosis in living cells [J].

Chen, CS ;

Martin, OC ;

Pagano, RE .

BIOPHYSICAL JOURNAL, 1997, 72 (01) :37-50

[4] Lipid lateral heterogeneity in phosphatidylcholine/phosphatidylserine/diacylglycerol vesicles and its influence on protein kinase C activation [J].

Dibble, ARG ;

Hinderliter, AK ;

Sando, JJ ;

Biltonen, RL .

BIOPHYSICAL JOURNAL, 1996, 71 (04) :1877-1890

[5]

Edidin M, 1996, CURR TOP MEMBR, V43, P1

[6]

FEDER T, 1993, BIOPHYS J, V70, P2767

[7] Cellular and molecular mechanics by atomic force microscopy: Capturing the exocytotic fusion pore in vivo? [J].

Fernandez, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (01) :9-10

[8] Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains [J].

Field, KA ;

Holowka, D ;

Baird, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (07) :4276-4280

[9] GPI-anchored proteins, glycosphingolipids, and sphingomyelin are sequestered to caveolae only after crosslinking [J].

Fujimoto, T .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1996, 44 (08) :929-941

[10] Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains [J].

Glaser, M ;

Wanaski, S ;

Buser, CA ;

Boguslavsky, V ;

Rashidzada, W ;

Morris, A ;

Rebecchi, M ;

Scarlata, SF ;

Runnels, LW ;

Prestwich, GD ;

Chen, J ;

Aderem, A ;

Ahn, J ;

McLaughlin, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (42) :26187-26193

← 1 2 3 4 5 →