Direct asymmetric alpha-hydroxylation of beta-hydroxyketones

被引：15

作者：

Lopp, M ^{[1
]}

Paju, A ^{[1
]}

Kanger, T ^{[1
]}

Pehk, T ^{[1
]}

机构：

[1] ESTONIAN ACAD SCI,INST CHEM PHYS & BIOPHYS,EE-0026 TALLINN,ESTONIA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(97)01102-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct oxidation of racemic beta-hydroxyketones 1a-c under Sharpless oxidation conditions resulted in the enantiomeric alpha,beta-dihydroxyketones 2a in 97% ee, 2b in 86% ee and 29 in 95% ee respectively, in 37-58% of isolated yield. The oxidation is assumed to proceed via an allylic enolate intermediate. (C) 1997 Elsevier Science Ltd.

引用

页码：5051 / 5054

页数：4

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