Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat

被引：80

作者：

Li, YP ^{[1
]}

机构：

[1] BAYLOR COLL MED,DEPT MOL PHYSIOL & BIOPHYS,HOUSTON,TX 77030

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 05期

关键词：

D O I：

10.1128/JVI.71.5.4098-4102.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nucleolar shuttle protein B23 was found to bind to human immunodeficiency virus protein Tat, and this binding required the nucleolar localization motif of Tat. A fusion protein containing the B23 binding domain and beta-galactosidase caused mislocalization of Tat to the cytoplasm and inhibited the transactivation activity of Tat, These data suggest that B23 is a human factor necessary for the nucleolar localization of Tat.

引用

页码：4098 / 4102

页数：5

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