共 15 条
It takes three to tango
被引:20
作者:

Lomovskaya, O
论文数: 0 引用数: 0
h-index: 0
机构:
Essential therapeut Inc, Efflux Biol, Mt View, CA 94043 USA Essential therapeut Inc, Efflux Biol, Mt View, CA 94043 USA

Zgurskaya, HI
论文数: 0 引用数: 0
h-index: 0
机构: Essential therapeut Inc, Efflux Biol, Mt View, CA 94043 USA

Nikaido, H
论文数: 0 引用数: 0
h-index: 0
机构: Essential therapeut Inc, Efflux Biol, Mt View, CA 94043 USA
机构:
[1] Essential therapeut Inc, Efflux Biol, Mt View, CA 94043 USA
[2] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA
[3] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
关键词:
D O I:
10.1038/nbt1202-1210
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
The recently determined high-resolution crystal structure of the bacterial multidrug resistance transporter AcrB brings us one step closer to the design of more effective therapeutic agents.
引用
收藏
页码:1210 / 1212
页数:4
相关论文
共 15 条
[1]
Transmembrane molecular pump activity of Niemann-Pick C1 protein
[J].
Davies, JP
;
Chen, FW
;
Ioannou, YA
.
SCIENCE,
2000, 290 (5500)
:2295-+

Davies, JP
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA

Chen, FW
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA

Ioannou, YA
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA
[2]
Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominately by two large periplasmic loops
[J].
Elkins, CA
;
Nikaido, H
.
JOURNAL OF BACTERIOLOGY,
2002, 184 (23)
:6490-6498

Elkins, CA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

Nikaido, H
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
[3]
Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa
[J].
Guan, L
;
Nakae, T
.
JOURNAL OF BACTERIOLOGY,
2001, 183 (05)
:1734-1739

Guan, L
论文数: 0 引用数: 0
h-index: 0
机构:
Tokai Univ, Sch Med, Dept Mol Life Sci, Isehara, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Mol Life Sci, Isehara, Kanagawa 2591193, Japan

Nakae, T
论文数: 0 引用数: 0
h-index: 0
机构:
Tokai Univ, Sch Med, Dept Mol Life Sci, Isehara, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Mol Life Sci, Isehara, Kanagawa 2591193, Japan
[4]
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
[J].
Koronakis, V
;
Sharff, A
;
Koronakis, E
;
Luisi, B
;
Hughes, C
.
NATURE,
2000, 405 (6789)
:914-919

Koronakis, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

Sharff, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

Koronakis, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

Luisi, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

Hughes, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England
[5]
Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa:: Novel agents for combination therapy
[J].
Lomovskaya, O
;
Warren, MS
;
Lee, A
;
Galazzo, J
;
Fronko, R
;
Lee, M
;
Blais, J
;
Cho, D
;
Chamberland, S
;
Renau, T
;
Leger, R
;
Hecker, S
;
Watkins, W
;
Hoshino, K
;
Ishida, H
;
Lee, VJ
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
2001, 45 (01)
:105-116

Lomovskaya, O
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Warren, MS
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Lee, A
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Galazzo, J
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Fronko, R
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Lee, M
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Blais, J
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Cho, D
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Chamberland, S
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Renau, T
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Leger, R
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Hecker, S
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Watkins, W
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Hoshino, K
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Ishida, H
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA

Lee, VJ
论文数: 0 引用数: 0
h-index: 0
机构: Microcide Pharmaceut Inc, Mountain View, CA 94043 USA
[6]
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
[J].
Ma, Y
;
Erkner, A
;
Gong, RY
;
Yao, SQ
;
Taipale, J
;
Basler, K
;
Beachy, PA
.
CELL,
2002, 111 (01)
:63-75

Ma, Y
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

Erkner, A
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

Gong, RY
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

Yao, SQ
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

Taipale, J
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

Basler, K
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

Beachy, PA
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA
[7]
On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps:: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition
[J].
Mao, WM
;
Warren, MS
;
Black, DS
;
Satou, T
;
Murata, T
;
Nishino, T
;
Gotoh, N
;
Lomovskaya, O
.
MOLECULAR MICROBIOLOGY,
2002, 46 (03)
:889-901

Mao, WM
论文数: 0 引用数: 0
h-index: 0
机构: Essential Therapeut Inc, Mt View, CA 94043 USA

Warren, MS
论文数: 0 引用数: 0
h-index: 0
机构: Essential Therapeut Inc, Mt View, CA 94043 USA

Black, DS
论文数: 0 引用数: 0
h-index: 0
机构: Essential Therapeut Inc, Mt View, CA 94043 USA

Satou, T
论文数: 0 引用数: 0
h-index: 0
机构: Essential Therapeut Inc, Mt View, CA 94043 USA

Murata, T
论文数: 0 引用数: 0
h-index: 0
机构: Essential Therapeut Inc, Mt View, CA 94043 USA

Nishino, T
论文数: 0 引用数: 0
h-index: 0
机构: Essential Therapeut Inc, Mt View, CA 94043 USA

Gotoh, N
论文数: 0 引用数: 0
h-index: 0
机构: Essential Therapeut Inc, Mt View, CA 94043 USA

Lomovskaya, O
论文数: 0 引用数: 0
h-index: 0
机构: Essential Therapeut Inc, Mt View, CA 94043 USA
[8]
Crystal structure of bacterial multidrug efflux transporter AcrB
[J].
Murakami, S
;
Nakashima, R
;
Yamashita, E
;
Yamaguchi, A
.
NATURE,
2002, 419 (6907)
:587-593

Murakami, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Inst Sci & Ind Res, Dept Cell Membrane Biol, Osaka 5670047, Japan

Nakashima, R
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Inst Sci & Ind Res, Dept Cell Membrane Biol, Osaka 5670047, Japan

论文数: 引用数:
h-index:
机构:

Yamaguchi, A
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Inst Sci & Ind Res, Dept Cell Membrane Biol, Osaka 5670047, Japan Osaka Univ, Inst Sci & Ind Res, Dept Cell Membrane Biol, Osaka 5670047, Japan
[9]
Multidrug resistance in Gram-negative bacteria
[J].
Poole, K
.
CURRENT OPINION IN MICROBIOLOGY,
2001, 4 (05)
:500-508

Poole, K
论文数: 0 引用数: 0
h-index: 0
机构:
Queens Univ, Dept Microbiol & Immunol, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Microbiol & Immunol, Kingston, ON K7L 3N6, Canada
[10]
Patched acts catalytically to suppress the activity of Smoothened
[J].
Taipale, J
;
Cooper, MK
;
Maiti, T
;
Beachy, PA
.
NATURE,
2002, 418 (6900)
:892-897

Taipale, J
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Howard Hughes Med Inst, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Howard Hughes Med Inst, Baltimore, MD 21205 USA

Cooper, MK
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Howard Hughes Med Inst, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Howard Hughes Med Inst, Baltimore, MD 21205 USA

Maiti, T
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Howard Hughes Med Inst, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Howard Hughes Med Inst, Baltimore, MD 21205 USA

Beachy, PA
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Howard Hughes Med Inst, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Howard Hughes Med Inst, Baltimore, MD 21205 USA