It takes three to tango

被引:20
作者
Lomovskaya, O [1 ]
Zgurskaya, HI
Nikaido, H
机构
[1] Essential therapeut Inc, Efflux Biol, Mt View, CA 94043 USA
[2] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA
[3] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
关键词
D O I
10.1038/nbt1202-1210
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The recently determined high-resolution crystal structure of the bacterial multidrug resistance transporter AcrB brings us one step closer to the design of more effective therapeutic agents.
引用
收藏
页码:1210 / 1212
页数:4
相关论文
共 15 条
[1]   Transmembrane molecular pump activity of Niemann-Pick C1 protein [J].
Davies, JP ;
Chen, FW ;
Ioannou, YA .
SCIENCE, 2000, 290 (5500) :2295-+
[2]   Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominately by two large periplasmic loops [J].
Elkins, CA ;
Nikaido, H .
JOURNAL OF BACTERIOLOGY, 2002, 184 (23) :6490-6498
[3]   Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa [J].
Guan, L ;
Nakae, T .
JOURNAL OF BACTERIOLOGY, 2001, 183 (05) :1734-1739
[4]   Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export [J].
Koronakis, V ;
Sharff, A ;
Koronakis, E ;
Luisi, B ;
Hughes, C .
NATURE, 2000, 405 (6789) :914-919
[5]   Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa:: Novel agents for combination therapy [J].
Lomovskaya, O ;
Warren, MS ;
Lee, A ;
Galazzo, J ;
Fronko, R ;
Lee, M ;
Blais, J ;
Cho, D ;
Chamberland, S ;
Renau, T ;
Leger, R ;
Hecker, S ;
Watkins, W ;
Hoshino, K ;
Ishida, H ;
Lee, VJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (01) :105-116
[6]   Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched [J].
Ma, Y ;
Erkner, A ;
Gong, RY ;
Yao, SQ ;
Taipale, J ;
Basler, K ;
Beachy, PA .
CELL, 2002, 111 (01) :63-75
[7]   On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps:: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition [J].
Mao, WM ;
Warren, MS ;
Black, DS ;
Satou, T ;
Murata, T ;
Nishino, T ;
Gotoh, N ;
Lomovskaya, O .
MOLECULAR MICROBIOLOGY, 2002, 46 (03) :889-901
[8]   Crystal structure of bacterial multidrug efflux transporter AcrB [J].
Murakami, S ;
Nakashima, R ;
Yamashita, E ;
Yamaguchi, A .
NATURE, 2002, 419 (6907) :587-593
[9]   Multidrug resistance in Gram-negative bacteria [J].
Poole, K .
CURRENT OPINION IN MICROBIOLOGY, 2001, 4 (05) :500-508
[10]   Patched acts catalytically to suppress the activity of Smoothened [J].
Taipale, J ;
Cooper, MK ;
Maiti, T ;
Beachy, PA .
NATURE, 2002, 418 (6900) :892-897