RIG-I-like receptors: Sensing and responding to RNA virus infection

被引：174

作者：

Nakhaei, Peyman ^{[1
,2
]}

Genin, Pierre ^{[4
]}

Civas, Ahmet ^{[4
]}

Hiscott, John ^{[1
,2
,3
]}

机构：

[1] Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3T 1E2, Canada

[3] McGill Univ, Dept Med, Montreal, PQ H3T 1E2, Canada

[4] Univ Paris 05, CNRS, Lab Regulat Transcript & Malad Genet, UFR Biomed St Peres,UPR 2228, F-75270 Paris 06, France

来源：

SEMINARS IN IMMUNOLOGY | 2009年 / 21卷 / 04期

基金：

加拿大健康研究院;

关键词：

RIG-I; MDA-5; MAVS; STING; RNA virus; TOLL-LIKE RECEPTOR; NF-KAPPA-B; INNATE IMMUNE-RESPONSES; DOUBLE-STRANDED-RNA; HEPATITIS-C VIRUS; IFN-BETA PROMOTER; INDUCIBLE GENE-I; DIFFERENTIATION-ASSOCIATED GENE-5; INDEPENDENT ANTIVIRAL RESPONSE; TUMOR-SUPPRESSOR CYLD;

D O I：

10.1016/j.smim.2009.05.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viral and microbial pathogens contain specific motifs or pathogen-associated molecular patterns (PAMPs) that are recognized by cell surface-and endosome-associated Toll-like receptors (TLRs). RNA virus infection is also detected through TLR-independent mechanisms. Early viral replicative intermediates are detected by two recently characterized cystolic viral RNA receptors-RIG-I and MDA-5. Both are DExDH/box RNA helicases, and RIG-I specifically recognizes 5'-triphosphate containing viral RNA and transmits signals that induce type I interferon-mediated host immunity against virus infection. In this review, we will focus on RIG-I-like receptor (RLR) signal transduction and the regulatory mechanisms ubiquitination, deubiquitination, ISGylation - underlying this important host response. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：215 / 222

页数：8

共 89 条

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