The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn

被引：250

作者：

Abraira, Victoria E. ^{[1
]}

Kuehn, Emily D. ^{[1
,2
]}

Chirila, Anda M. ^{[1
]}

Springel, Mark W. ^{[1
]}

Toliver, Alexis A. ^{[1
]}

Zimmerman, Amanda L. ^{[1
]}

Orefice, Lauren L. ^{[1
]}

Boyle, Kieran A. ^{[3
]}

Bai, Ling ^{[1
,2
]}

Song, Bryan J. ^{[1
]}

Bashista, Karleena A. ^{[1
]}

O'Neill, Thomas G. ^{[1
]}

Zhuo, Justin ^{[1
]}

Tsan, Connie ^{[1
]}

Hoynoski, Jessica ^{[1
]}

Rutlin, Michael ^{[4
,5
,9
,10
]}

Kus, Laura ^{[6
]}

Niederkofler, Vera ^{[7
]}

Watanabe, Masahiko ^{[8
]}

Dymecki, Susan M. ^{[7
]}

Nelson, Sacha B. ^{[4
,5
]}

Heintz, Nathaniel ^{[6
]}

Hughes, David I. ^{[3
]}

Ginty, David D. ^{[1
]}

机构：

[1] Harvard Med Sch, Howard Hughes Med Inst, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA

[2] Johns Hopkins Univ, Sch Med, Neurosci Training Program, Baltimore, MD 21205 USA

[3] Univ Glasgow, Inst Neurosci & Psychol, Glasgow G12 8QQ, Lanark, Scotland

[4] Brandeis Univ, Dept Biol, Waltham, MA 02453 USA

[5] Brandeis Univ, Natl Ctr Behav Genom, Waltham, MA 02453 USA

[6] Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10065 USA

[7] Harvard Med Sch, Dept Genet, 77 Ave Louis Pasteur, Boston, MA 02115 USA

[8] Hokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 0608638, Japan

[9] Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

[10] Columbia Univ, Howard Hughes Med Inst, Dept Neurosci, New York, NY 10032 USA

来源：

CELL | 2017年 / 168卷 / 1-2期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

RAT SPINAL-CORD; LAMINAE I-III; GABAERGIC NEURONS; ELECTROPHYSIOLOGICAL FEATURES; CORTICOSPINAL TRACT; EXPRESSING NEURONS; CURRENT INJECTION; CEREBRAL-CORTEX; MOUSE; IDENTIFICATION;

D O I：

10.1016/j.cell.2016.12.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR-recipient zone (LTMR-RZ), a role for LTMR-RZ processing in tactile perception, and the basic logic of LTMR-RZ organization. We found an unexpectedly high degree of neuronal diversity in the LTMR-RZ: seven excitatory and four inhibitory subtypes of interneurons exhibiting unique morphological, physiological, and synaptic properties. Remarkably, LTMRs form synapses on between four and 11 LTMR-RZ interneuron subtypes, while each LTMR-RZ interneuron subtype samples inputs from at least one to three LTMR classes, as well as spinal cord interneurons and corticospinal neurons. Thus, the LTMR-RZ is a somatosensory processing region endowed with a neuronal complexity that rivals the retina and functions to pattern the activity of ascending touch pathways that underlie tactile perception.

引用

页码：295 / +

页数：35

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