Synthesis, characterization, interaction with DNA, and antitumor activity of a cis-Dichloroplatinum(II) complex linked to an intercalator via one methylene chain

被引：13

作者：

Mikata, Y

Mogami, K

Kato, M

Okura, I

Yano, SB

机构：

[1] NARA WOMENS UNIV,FAC SCI,DEPT CHEM,NARA 630,JAPAN

[2] TOKYO INST TECHNOL,DEPT BIOENGN,YOKOHAMA,KANAGAWA 226,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(97)00167-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A cisplatin-type complex tethered to acridine intercalator via one methylene chain has been synthesized. Its structure was elucidated by X-ray crystallography. A permeability into cell, interaction with calf thymus DNA (ct-DNA), and antitumor activity against HeLa and P388 cells were studied. (C) 1997 Elsevier Science Ltd.

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页码：1083 / 1086

页数：4

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