The epigenomics of cancer

被引：3586

作者：

Jones, Peter A. ^{[1
]}

Baylin, Stephen B.

机构：

[1] Univ So Calif, Dept Urol Biochem & Mol Biol, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Los Angeles, CA 90089 USA

[2] Johns Hopkins Med Inst, Canc Biol Program, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

CELL | 2007年 / 128卷 / 04期

关键词：

D O I：

10.1016/j.cell.2007.01.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer. © 2007 Elsevier Inc. All rights reserved.

引用

页码：683 / 692

页数：10

共 90 条

[1] GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer
Akiyama, Y
Watkins, N
Suzuki, H
Jair, KW
van Engeland, M
Esteller, M
Sakai, H
Ren, CY
Yuasa, Y
Herman, JG
Baylin, SB
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (23) : 8429 - 8439
[2] Prospective identification of tumorigenic breast cancer cells
Al-Hajj, M
Wicha, MS
Benito-Hernandez, A
Morrison, SJ
Clarke, MF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 3983 - 3988
[3] Methyl-CpG binding domain protein 2 represses transcription from hypermethylated π-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells
Bakker, J
Lin, XH
Nelson, WG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (25) : 22573 - 22580
[4] Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?
Baylin, SB
Ohm, JE
[J]. NATURE REVIEWS CANCER, 2006, 6 (02) : 107 - 116
[5] Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis
Belinsky, SA
Nikula, KJ
Palmisano, WA
Michels, R
Saccomanno, G
Gabrielson, E
Baylin, SB
Herman, JG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) : 11891 - 11896
[6] A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, BE
Mikkelsen, TS
Xie, XH
Kamal, M
Huebert, DJ
Cuff, J
Fry, B
Meissner, A
Wernig, M
Plath, K
Jaenisch, R
Wagschal, A
Feil, R
Schreiber, SL
Lander, ES
[J]. CELL, 2006, 125 (02) : 315 - 326
[7] Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin
Bernstein, E
Duncan, EM
Masui, O
Gil, J
Heard, E
Allis, CD
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (07) : 2560 - 2569
[8] Opinion - The origin of the cancer stem cell: current controversies and new insights
Bjerkvig, R
Tysnes, BB
Aboody, KS
Najbauer, J
Terzis, AJA
[J]. NATURE REVIEWS CANCER, 2005, 5 (11) : 899 - 904
[9] Anticancer activities of histone deacetylase inhibitors
Bolden, Jessica E.
Peart, Melissa J.
Johnstone, Ricky W.
[J]. NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (09) : 769 - 784
[10] Polycomb complexes repress developmental regulators in murine embryonic stem cells
Boyer, LA
Plath, K
Zeitlinger, J
Brambrink, T
Medeiros, LA
Lee, TI
Levine, SS
Wernig, M
Tajonar, A
Ray, MK
Bell, GW
Otte, AP
Vidal, M
Gifford, DK
Young, RA
Jaenisch, R
[J]. NATURE, 2006, 441 (7091) : 349 - 353

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