Genetic polymorphism of CYP2A6 in the German population

被引：22

作者：

Bourian, M

Gullstén, H

Legrum, W

机构：

[1] Univ Marburg, Inst Pharmacol & Toxicol, D-35034 Marburg, Germany

[2] Univ Oulu, Dept Pharmacol & Toxicol, Oulu 90401, Finland

来源：

TOXICOLOGY | 2000年 / 144卷 / 1-3期

关键词：

pharmacogenetics; CYP2A6; genetic polymorphism; poor/extensive metabolizer; ethnic differences;

D O I：

10.1016/S0300-483X(99)00199-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Genetic polymorphism of drug metabolizing enzymes (DME) can lead to severe toxicity or therapeutic failure of pharmacotherapy. Additionally, genetically determined differences in the activity of the metabolic enzymes can increase an individual's susceptibility to certain types of chemically induced cancers and possibly other diseases. Cytochrome P450 is one of the most important metabolic systems of the organism involved in the oxidation of different xenobiotics. This contribution summarizes and updates the information concerning the genetic polymorphism of the CYP2A6 isoform of the cytochrome P450. A special emphasis is put upon the genotyping techniques of CYP2AG with a comparative analysis of their predictable sensitivity and specificity given on the example of the German population. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：129 / 137

页数：9

共 32 条

[1] COMPARISON OF A NOVEL THIN-LAYER CHROMATOGRAPHIC-FLUORESCENCE DETECTION METHOD WITH A SPECTROFLUOROMETRIC METHOD FOR THE DETERMINATION OF 7-HYDROXYCOUMARIN IN HUMAN URINE [J].