Aph(3′)-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia

被引：77

作者：

Okazaki, Aki ^{[1
]}

Avison, Matthew B. ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Cellular & Mol Med, Bristol Ctr Antimicrobial Res & Evaluat, Bristol BS8 1TD, Avon, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 01期

关键词：

DEFINED PHYLOGENETIC-RELATIONSHIPS; BETA-LACTAMASE EXPRESSION; PHOSPHOTRANSFERASE GENE; PSEUDOMONAS-AERUGINOSA; NUCLEOTIDE-SEQUENCE; TRANSPOSON; L1;

D O I：

10.1128/AAC.00795-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the characterization of an intrinsic, chromosomally carried aph(3')-IIc gene from Stenotrophomonas maltophilia clinical isolate K279a, encoding an aminoglycoside phosphotransferase enzyme that significantly increases MICs of kanamycin, neomycin, butirosin, and paromomycin when expressed in Escherichia coli. Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs.

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页码：359 / 360

页数：2

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