Clotting, Immune System, and Venous Thrombosis in Lung Adenocarcinoma Patients: A Prospective Study

被引：23

作者：

de Meis, Ernesto ^{[1
]}

Pinheiro, Vera R.

Zamboni, Mauro M.

Guedes, Maria Teresa S.

Castilho, Ilda A. M.

Martinez, Maria Mercedes K.

Leda, Marys Stella O.

Silveira, Neura P. R.

Rumjanek, Vivian M. ^{[2
]}

Levy, Roger A. ^{[3
]}

机构：

[1] Inst Nacl Canc, Clin Pathol Serv, BR-20230130 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Bioquim Med, Tumor Immunol Lab, BR-21941 Rio De Janeiro, Brazil

[3] Hosp Univ Pedro Ernesto, Rheumatol Discipline, Rio De Janeiro, Brazil

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 10期

关键词：

Lung adenocarcinoma; Thrombosis; Interleukin; Antiphospholipid; ANTIPHOSPHOLIPID SYNDROME; TISSUE FACTOR; ANTIBODIES; CANCER; THROMBOEMBOLISM; INFLAMMATION; ACTIVATION;

D O I：

10.3109/07357900903124464

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Thrombosis is highly prevalent in cancer patients, being accepted as a bad prognosis marker. The importance of various mechanisms involved in the thrombophilic state of lung cancer patients is not well understood. In this prospective study, involving 109 unselected patients with lung adenocarcinoma, thrombosis was present in 24% of patients and affected survival in a bivariable model. However, in a multivariable evaluation, considering all the factors under study, only LAC and IgM anti-beta(2) GP I modified thrombosis risk, whereas in a Kaplan-Meyer regression model, thrombosis, IL-6, LAC, factor VIII, and IgM anti-beta(2) GP I interfered with patient's survival.

引用

页码：989 / 997

页数：9

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