Recombinant hirudin as an alternative for anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II: A 1-year experience in 57 patients

Objective: To explore the possible use of recombinant hirudin (r-hirudin) as an alternative to heparin for anticoagulation during cardiovascular surgery. Design: Retrospective analysis. Setting: Two university hospitals. Participants: Fifty-seven patients with heparin-induced thrombocytopenia type II(HIT II) in whom r-hirudin was used during cardiovascular surgery with cardiopulmonary bypass (CPB). Interventions: None. Measurements and Main Results: The r-hirudin concentration was monitored on-line, at the point of the patient's care using the ecarin clotting time and maintained in the range of 3 to 4 mu g/mL. The r-hirudin elimination at the conclusion of CPB was augmented through modified zero-balanced ultrafiltration and forced diuresis. The duration of CPB was 63 to 246 minutes. The r-hirudin requirement per minute bf CPB was 0.016 to 0.035 mu g/kg/min, and the 24-hour blood drainage was 50 to 2,200 mL. Of the 57 patients, 54 fully recovered, including 9 patients who did not require any allogenic products. Four patients, all with impaired renal function, showed prolonged r-hirudin elimination and excessive breeding and required surgical reexploration. Three patients died as a result of complications unrelated to the perioperative management. Conclusion: This study provides evidence that r-hirudin can be used safely and effectively for routine anticoagulation during CPB in patients diagnosed with HIT II. Almost 95% of the patients in whom it was used were discharged uneventfully. Patients with perioperative renal failure, however, showed increased bleeding. Copyright (C) 2000 by W.B. Saunders Company.