A genome-wide affected sibpair linkage analysis of hypertension: The HyperGEN network

被引：54

作者：

Rao, DC

Province, MA

Leppert, MF

Oberman, A

Heiss, G

Ellison, RC

Arnett, DK

Eckfeldt, JH

Schwander, K

Mockrin, SC

Hunt, SC

机构：

[1] Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA

[2] Univ Utah, Salt Lake City, UT USA

[3] Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA

[4] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

[5] Boston Univ, Med Ctr, Prevent Med & Epidemiol Sect, Boston, MA 02215 USA

[6] Univ Minnesota, Hosp & Clin, Div Epidemiol, Minneapolis, MN USA

[7] NHLBI, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 2003年 / 16卷 / 02期

关键词：

linkage; hypertension; genetics;

D O I：

10.1016/S0895-7061(02)03247-8

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes. (C) 2003 American Journal of Hypertension, Ltd.

引用

页码：148 / 150

页数：3

共 9 条

[1] Genome-wide linkage analysis of blood pressure in Mexican Americans [J].