Impact of the Interaction Between the 5HTTLPR Polymorphism and Maltreatment on Adolescent Depression. A Population-Based Study

被引：64

作者：

Aslund, Cecilia ^{[1
]}

Leppert, Jerzy ^{[1
]}

Comasco, Erika ^{[1
,2
]}

Nordquist, Niklas ^{[2
]}

Oreland, Lars ^{[2
]}

Nilsson, Kent W. ^{[1
]}

机构：

[1] Uppsala Univ, Clin Res Ctr, Cent Hosp, S-72189 Vasteras, Sweden

[2] Uppsala Univ, Dept Neurosci, Pharmacol Unit, S-75105 Uppsala, Sweden

来源：

BEHAVIOR GENETICS | 2009年 / 39卷 / 05期

基金：

瑞典研究理事会;

关键词：

Depression; Serotonin transporter; Child maltreatment; Sex characteristics; 5HTTLPR; Gene-environment interaction; SEROTONIN TRANSPORTER GENE; STRESSFUL LIFE EVENTS; MAO-A GENE; FUNCTIONAL POLYMORPHISM; PROMOTER POLYMORPHISM; 5-HTTLPR POLYMORPHISM; PERSONALITY-TRAITS; GENDER-DIFFERENCES; MAJOR DEPRESSION; ASSOCIATION;

D O I：

10.1007/s10519-009-9285-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Serotonin plays a central role in mood regulation and the development of depressive disorders. The present study investigated whether a functional polymorphism (5HTTLPR) of the serotonin transporter gene interacts with maltreatment in the prediction of depression. A cohort of 17-18 years old students (n = 1,482) anonymously completed the Survey of Adolescent Life and Health in Vestmanland 2006 and gave a saliva sample for DNA extraction. An association between maltreatment and adolescent depression was found independent of sex. When the whole population was analyzed, no main effect of 5HTTLPR in association with depression was found. When separated by sex, a significant main effect and a G x E interaction effect of the SS allele was found among girls. No gene main effect or G x E interaction effect was found among boys. The present study confirms previous findings of sex differences in interaction effects between the 5HTTLPR polymorphism and maltreatment in the prediction of adolescent depression.

引用

页码：524 / 531

页数：8

共 50 条

[1]

[Anonymous], 2003, BLANK SLATE MODERN D

[2]

APA A.P. A., 2000, Diagnostic and statistical manual of mental disorders: DSM-IV, V4th

[3]

ARAYA R, 2008, AM J MED GENET B

[4] Sex difference in 5HT(2) receptor in the living human brain [J].

Biver, F ;

Lotstra, F ;

Monclus, M ;

Wikler, D ;

Damhaut, P ;

Mendlewicz, J ;

Goldman, S .

NEUROSCIENCE LETTERS, 1996, 204 (1-2) :25-28

[5] 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion [J].

Brummett, Beverly H. ;

Muller, Christopher L. ;

Collins, Ann L. ;

Boyle, Stephen H. ;

Kuhn, Cynthia M. ;

Siegler, Ilene C. ;

Williams, Redford B. ;

Ashley-Koch, Allison .

BEHAVIOR GENETICS, 2008, 38 (05) :476-483

[6] Associations among central nervous system serotonergic function and neuroticism are moderated by gender [J].

Brummett, Beverly H. ;

Boyle, Stephen H. ;

Kuhn, Cynthia M. ;

Siegler, Ilene C. ;

Williams, Redford B. .

BIOLOGICAL PSYCHOLOGY, 2008, 78 (02) :200-203

[7] Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR) [J].

Brummett, Beverly H. ;

Boyle, Stephen H. ;

Siegler, Ilene C. ;

Kuhn, Cynthia M. ;

Ashley-Koch, Allison ;

Jonassaint, Charles R. ;

Zuchner, Stephan ;

Collins, Ann ;

Williams, Redford B. .

BEHAVIOR GENETICS, 2008, 38 (01) :34-43

[8] Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene [J].

Caspi, A ;

Sugden, K ;

Moffitt, TE ;

Taylor, A ;

Craig, IW ;

Harrington, H ;

McClay, J ;

Mill, J ;

Martin, J ;

Braithwaite, A ;

Poulton, R .

SCIENCE, 2003, 301 (5631) :386-389

[9] The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype:: evidence from the Spanish PREDICT-Gene cohort [J].

Cervilla, J. A. ;

Molina, E. ;

Rivera, M. ;

Torres-Gonzalez, F. ;

Bellon, J. A. ;

Moreno, B. ;

Luna, J. D. ;

Lorente, J. A. ;

Mayoral, F. ;

King, M. ;

Nazareth, I. ;

Gutierrez, B. .

MOLECULAR PSYCHIATRY, 2007, 12 (08) :748-755

[10] No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: Results from two community surveys [J].

Chipman, P. ;

Jorm, A. F. ;

Prior, M. ;

Sanson, A. ;

Smart, D. ;

Tan, X. ;

Easteal, S. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2007, 144B (04) :561-565

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