Polymer-supported synthesis as a tool for improving chemoselectivity: Pauson-Khand reaction

被引：25

作者：

Spitzer, JL

Kurth, MJ

Schore, NE

机构：

[1] UNIV CALIF DAVIS,DEPT CHEM,DAVIS,CA 95616

[2] AL QUDS UNIV,DEPT CHEM,COLL SCI & TECHNOL,JERUSALEM,ISRAEL

来源：

TETRAHEDRON | 1997年 / 53卷 / 20期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4020(97)00386-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Intermolecular Pauson-Khand (PK) reactions of norbornene-derived substrates have been carried out with several alpha,omega-alkynols under both normal homogeneous conditions and with the alkynol bound to functionalized Merrifield's polymer beads. With 2% crosslinked resin chemoselectivity Favoring PK product Formation over alkyne trimerization and other related side reactions is enhanced over that found either in solution or on 1% crosslinked polymer. Alkynol chain length and nature of the linker also significantly affect the outcome of the polymer-supported process. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：6791 / 6808

页数：18

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