Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases

被引：44

作者：

Cockcroft, Shamshad ^{[1
]}

机构：

[1] UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2009年 / 1791卷 / 09期

基金：

英国惠康基金;

关键词：

PIP; 5-kinase; Phosphatidylinositol(4,5)bisphosphate; ARF; Phosphatidic acid; ADP-RIBOSYLATION-FACTOR; PHOSPHOLIPASE-D ACTIVITY; EPIDERMAL-GROWTH-FACTOR; PROTEIN-KINASE-C; RBL-2H3; MAST-CELLS; PLASMA-MEMBRANE; 4,5-BISPHOSPHATE SYNTHESIS; DOWNSTREAM EFFECTOR; DIRECTLY INTERACTS; HUMAN-NEUTROPHILS;

D O I：

10.1016/j.bbalip.2009.03.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatidic acid (PA) production by receptor-stimulated phospholipase D is believed to play an important role in the regulation of cell function. The second messenger function of PA remains to be elucidated. PA can bind and affect the activities of different enzymes and here we summarise the current status of activation of Type I phosphatidylinositol 4-phosphate 5-kinase by PA. Type 1 phosphatidylinositol 4-phosphate 5-kinase is also regulated by ARF proteins as is phospholipase D and we discuss the contributions of ARF and PA towards phosphatidylinositol(4,5)bisphosphate synthesis at the plasma membrane. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：905 / 912

页数：8

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